Results 91 to 100 of about 3,041,459 (262)

Should We Measure Fetal Omphalocele Diameter for Prediction of Perinatal Outcome?

, 2014
Objective: To evaluate the fetal omphalocele diameter/abdominal circumference ratio (OD/AC) as a predictor of adverse perinatal outcome. Methods: Analysis involving 47 singleton pregnancies with fetal omphalocele, normal karyotype and absence of other ...
Liao, Adolfo W., Kiyohara, Marina Y., Brizot, Maria L., Francisco, Rossana P. V., Krebs, Vera L. J., Tannuri, Ana C. A., Zugaib, Marcelo [UNIFESP]   +6 more
core   +1 more source

Prenatal ultrasound screening for fetal anomalies and outcomes in high-risk pregnancies due to maternal HIV infection : a retrospective study [PDF]

, 2013
Objective: To assess the prevalence of prenatal screening and of adverse outcome in high-risk pregnancies due to maternal HIV infection. Study design: The prevalence of prenatal screening in 330 pregnancies of HIV-positive women attending the ...
Louwen, Frank, Herrmann, Eva, Buxmann, Horst, Reitter, Anke, Stücker, Anja-Undine, Haberl, Annette Elisabeth, Schlößer, Rolf Lambert   +6 more
core   +1 more source

Prenatal Diagnosis of Fryns Syndrome through Identification of Two Novel Splice Variants in the PIGN Gene—A Case Series

Life
Fryns syndrome (FS) is a multiple congenital anomaly syndrome with different multisystemic malformations. These include congenital diaphragmatic hernia, pulmonary hypoplasia, and craniofacial dysmorphic features in combination with malformations of the ...
Aruna Marchetto, Susanne Leidescher, Theresia van Hoi, Niklas Hirschberger, Florian Vogel, Siegmund Köhler, Ivonne Alexandra Bedei, Roland Axt-Fliedner, Moneef Shoukier, Corinna Keil   +9 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Indication for delivery and neonatal outcomes in prenatally diagnosed gastroschisis: A 20‐year retrospective cohort study

Pregnancy
Background The optimal timing and indication for delivery in gastroschisis remain subjects of ongoing debate. This study evaluates clinical characteristics and postnatal outcomes associated with varying indications for delivery in this population ...
Nikan Zargarzadeh, Giulia Bonanni, Enaja Sambatur, Ehsan Rojhani, Eyal Krispin, Kjersti Aagaard, Alireza A. Shamshirsaz   +6 more
doaj   +1 more source

Transplanted gene-modified placental cells boost FVIII activity in pediatric sheep without eliciting immunity, toxicity, or adverse events

Frontiers in Immunology
BackgroundThe current standard of care for Hemophilia A (HA), a hereditary bleeding disorder caused by mutations in the Factor VIII (F8) gene, include FVIII replacement proteins, engineered clotting factors, and a broad array of new therapeutics ...
Brady Trevisan, Martin Rodriguez, Ritu Ramamurthy, Sunil George, Oluwaseun O. Babatunde, Jacqueline Dizon, Jordan Shields, Shannon Lankford, Denise Schwahn, Michael Gautreaux, Andrew Farland, John Owen, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada   +16 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Elevated fetal steroidogenic activity in autism [PDF]

, 2015
Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor.
Cohen, A. S., Melgaard, L, Melgaard, L., M W Abdallah, Abdallah, M. W., D M Hougaard, Hougaard, D M, S Baron-Cohen, Baron-Cohen, S., M V Lombardo, B Auyeung, Auyeung, B., Ruta, L., B Chakrabarti, L Melgaard, Auyeung, B; id_orcid, Chakrabarti, Bhisma, Lombardo, M V, Nørgaard-Pedersen, B., B Nørgaard-Pedersen, A S Cohen, Abdallah, M W, Nørgaard-Pedersen, B, Ruta, L, Lombardo, M. V., Baron-Cohen, S, Chakrabarti, B, L Ruta, Cohen, A S, Hougaard, D. M.   +29 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT

Acta Obstetricia et Gynecologica Scandinavica
Introduction Tetralogy of Fallot (ToF) shows variability in neonatal outcomes, and identifying reliable prenatal predictors is essential for optimizing perinatal management.
Laura Nogué, Mar Bennasar, Laura Guirado, Felix Zölner, Justus Reitz, Roland Axt‐Fliedner, María C. Escobar‐Díaz, Josep Maria Martínez, Eduard Gratacós, Fàtima Crispi, Olga Gómez, for the BCNatal and Gießen and Marburg University investigators   +11 more
doaj   +1 more source