Results 11 to 20 of about 405,974 (257)

Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity

Nature Communications, 2023
Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII levels 3 years post-treatment.
Martin Rodriguez, Brady Trevisan, Ritu M. Ramamurthy, Sunil K. George, Jonathan Diaz, Jordan Alexander, Diane Meares, Denise J. Schwahn, David R. Quilici, Jorge Figueroa, Michael Gautreaux, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada   +16 more
doaj   +1 more source

Color Doppler Score: A New Approach for Monitoring a Large Placental Chorioangioma

Case Reports in Obstetrics and Gynecology, 2014
We employed color Doppler score as an innovative approach for the prenatal diagnosis and monitoring of a large placental chorioangioma case diagnosed at 26 weeks and the subjective semiquantitative assessment of the vascularization.
Maria Angelica Zoppi, Alessandra Piras, Ambra Iuculano, Maurizio Arras, Federica Mulas, Maria Carmela Fadda, Sergio Cossu, Giovanni Monni   +7 more
doaj   +1 more source

Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A

Molecular Therapy: Methods & Clinical Development, 2020
The delivery of factor VIII (FVIII) through gene and/or cellular platforms has emerged as a promising hemophilia A treatment. Herein, we investigated the suitability of human placental cells (PLCs) as delivery vehicles for FVIII and determined an optimal
Nadia El-Akabawy, Martin Rodriguez, Ritu Ramamurthy, Andrew Rabah, Brady Trevisan, Alshaimaa Morsi, Sunil George, Jordan Shields, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada   +14 more
doaj   +1 more source

Ultrasonographic Development of the Fetal Sheep Stomach and Evaluation of Early Gestation Ultrasound-guided In Utero Intragastric Injection

Taiwanese Journal of Obstetrics & Gynecology, 2010
Objective: Safely targeting the fetal gastrointestinal tract during early gestation is essential to develop effective prenatal gene therapy for gastrointestinal diseases.
Anna L. David, Khalil N. Abi-Nader, Boaz Weisz, S.W. Steven Shaw, Michael Themis, Terence Cook, Charles Coutelle, Charles H. Rodeck, Donald M. Peebles   +8 more
doaj   +1 more source

Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans

Metabolites, 2020
Infertility affects 12−15% of couples worldwide, and male factors are the cause of nearly half of all cases. Studying seminal fluid composition could lead to additional diagnostic accuracy and a better understanding of the pathophysiology of male ...
Federica Murgia, Valentina Corda, Marianna Serrenti, Valeria Usai, Maria Laura Santoru, K. Joseph Hurt, Mauro Passaretti, Maria Carla Monni, Luigi Atzori, Giovanni Monni   +9 more
doaj   +1 more source

Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A

Frontiers in Cell and Developmental Biology, 2021
Patients with the severe form of hemophilia A (HA) present with a severe phenotype, and can suffer from life-threatening, spontaneous hemorrhaging. While prophylactic FVIII infusions have revolutionized the clinical management of HA, this treatment is ...
Christopher Stem, Christopher Rodman, Ritu M. Ramamurthy, Sunil George, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada   +10 more
doaj   +1 more source

The Fetal Heart in Twin-to-Twin Transfusion Syndrome

International Journal of Pediatrics, 2010
Twin-to-twin transfusion syndrome is a severe complication occurring in 10% of monochorionic twin pregnancies. The disease is usually explained as due to an intrauterine imbalance in intertwin blood exchange, which leads to a volume depleted-donor twin ...
Tim Van Mieghem, Liesbeth Lewi, Léonardo Gucciardo, Philip DeKoninck, Dominique Van Schoubroeck, Roland Devlieger, Jan Deprest   +6 more
doaj   +1 more source

Dichorionic diamniotic heterotopic twin gestation with cesarean section scar implantation and placenta increta

Radiology Case Reports, 2023
Heterotopic cesarean scar pregnancy is an extremely rare form of pregnancy and is defined as an intrauterine pregnancy coexisting with an ectopic pregnancy implanted in the cesarean scar.
Felicia Wang, BA, Arthur Vaught, MD, Mara Rosner, MD, MPH, Ahmet Baschat, MD, Kristin Darwin, MD, Torre Halscott, MD, MS, Michelle Kush, MD, Jena Miller, MD, Erin Gomez, MD   +8 more
doaj   +1 more source

Prenatal Diagnosis of Cardiac Diverticulum with Pericardial Effusion in the First Trimester of Pregnancy with Resolution after Early Pericardiocentesis

Case Reports in Obstetrics and Gynecology, 2015
Cardiac diverticulum is a rare anomaly, which may present in association with pericardial effusion. Only few cases diagnosed during fetal life have been published and only in 12 cases pericardiocentesis was made with good postnatal outcomes in 83% of the
Raquel Garcia Rodriguez, Azahara Rodriguez Guedes, Raquel Garcia Delgado, Lourdes Roldan Gutierrez, Margarita Medina Castellano, Jose Angel Garcia Hernandez   +5 more
doaj   +1 more source

A closer look at discordant placental echogenicity: two cases under the microscope

Clinical Case Reports, 2021
Discordant placental echogenicity is observed in MC pregnancies complicated with twin anemia‐polycythemia sequence, but could also belong to complicated singleton gestation.
Mariano M. Lanna, Valentina Toto, Stefano Faiola, Daniela Casati, Gaetano P. Bulfamante, Irene Cetin, Maria Angela Rustico   +6 more
doaj   +1 more source