Results 41 to 50 of about 3,041,459 (262)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Percutaneous Laser Ablation of Sacrococcygeal Teratoma in a Hydropic Fetus with Severe Heart Failure - Too Late for a Surgical Procedure?

, 2009
Sacrococcygeal teratoma (SCT) is the commonest solid fetal tumor. Perinatal prognosis is usually favorable, but sometimes it can be complicated by fetal hydrops being responsible for high risk of mortality. Fetal therapy in such cases has so far not been
DUARTE, Sergio, ZUGAIB, Marcelo, RUANO, Rodrigo   +2 more
core   +1 more source

Fetal cells in maternal circulation : fetal cell separation and FISH analysis [PDF]

, 2005
This work focuses on the isolation of fetal cells from the blood of pregnant women, with the aim of developing safe, efficacious, non-invasive alternatives for prenatal diagnosis.
Babochkina, Tatiana Ivanovna
core   +1 more source

Metabolomics Analysis of Amniotic Fluid in Euploid Foetuses with Thickened Nuchal Translucency by Gas Chromatography-Mass Spectrometry

Life, 2021
Persistence of a fetal thickened nuchal translucency (NT), one of the most sensitive and specific individual markers of fetal disorders, is strongly correlated with the possibility of a genetic syndrome, congenital infections, or other malformations ...
Federica Murgia, Giovanni Monni, Valentina Corda, Aran J. Hendren, Giulia Paci, Alba Piras, Rosa M. Ibba, Luigi Atzori   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Repeat fetoscopic laser surgery for postlaser twin anemia polycythemia sequence and recurrent twin-to-twin transfusion syndrome: matched outcomes in a single-center cohort‡

The Journal of Maternal-Fetal & Neonatal Medicine
Background Fetoscopic laser surgery aims to treat Twin-to-Twin Transfusion Syndrome with a single procedure. In rare cases, missed or recanalized anastomoses lead to recurrent disease, either postlaser Twin Anemia Polycythemia Sequence (TAPS) or ...
Abby Birk, Ahmet Baschat, Jena Miller, Camille Shantz, Jessamine Jin, Mackenzie Simon-Collins, Sarah Olson, Kristin Voegtline, Denise Wolfson, Michelle Kush, Mara Rosner   +10 more
doaj   +1 more source

Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A

Frontiers in Bioengineering and Biotechnology, 2021
Microfluidic technology enables recapitulation of organ-level physiology to answer pertinent questions regarding biological systems that otherwise would remain unanswered.
Brady Trevisan, Alshaimaa Morsi, Alshaimaa Morsi, Julio Aleman, Martin Rodriguez, Jordan Shields, Diane Meares, Andrew M. Farland, Christopher B. Doering, H. Trent Spencer, Anthony Atala, Aleks Skardal, Christopher D. Porada, Graça Almeida-Porada   +13 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fetal Therapies and Maternal-Fetal Tolerance [PDF]

, 2016
The ability to diagnose and treat genetic diseases before birth represents one of the foremost breakthroughs of modern medicine. While fetal surgery has advanced in the last several decades, the prospect of applying developments in stem cell biology and ...
MacKenzie, Tippi, Tippi MacKenzie, Graca Almeida-Porada, Porada, Graca Almeida   +3 more
core   +1 more source

Arnold-chiari In A Fetal Rat Model Of Dysraphism.

, 2015
Dysraphism is a defect in neural tube development, leading to dysplastic growth of the spinal cord and meninges. Myelomeningocele (MM) is just one of its forms.
Weber Guimarães Barreto, Maria, Guimarães Bittencourt, Daniel, Barini, Ricardo, Sbragia, Lourenço, Violin Pereira, Luis A, Ferro, Marcelo M   +5 more
core   +2 more sources