Results 271 to 280 of about 1,544,983 (360)

Paracetamol and its metabolites in children and adults with spinal muscular atrophy – a population pharmacokinetic model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of the study was to investigate whether differences in paracetamol pharmacokinetics (PK) between spinal muscular atrophy (SMA) patients and healthy controls (HC) could be attributed to specific clinical covariates. Methods Nonlinear mixed‐effects modelling (NONMEM 7.4) was used to develop a population PK model, explore covariates ...
Qiaolin Zhao   +14 more
wiley   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai   +4 more
wiley   +1 more source

Profiling eyewash usage and preferences in individuals with hay fever using a digital cross-sectional cohort study with AllerSearch. [PDF]

open access: yesSci Rep
Inomata T   +7 more
europepmc   +1 more source

The Oropouche virus (OROV) and need of advanced diagnostics to mitigate it. [PDF]

open access: yesAnn Med Surg (Lond)
Patel SK   +6 more
europepmc   +1 more source

EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt   +7 more
wiley   +1 more source

Knowledge, perception and preventive practices of Lassa fever among mothers of under-five children in an endemic community in Edo State, Nigeria. [PDF]

open access: yesBMC Public Health
Saka SA   +9 more
europepmc   +1 more source

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