Results 1 to 10 of about 5,108 (173)

Triple-target small molecule for PRRSV and ASFV infections

Bioorganic Chemistry
Pigs are vital sources of food and biological products. However, viruses such as porcine reproductive and respiratory syndrome virus (PRRSV) and African swine fever virus (ASFV) pose significant threats to the global swine industry, resulting in substantial financial losses.
Youle, Zheng, Yanbin, Song, Jin, Feng, Defeng, Wen, Mengyu, Chang, Mengping, Song, Hua, Cao, Min, Ling, Yixin, Yu, Yanfei, Tao, Wentao, Li, Xu, Wang   +11 more
openaire   +2 more sources

ASFV subunit vaccines: Strategies and prospects for future development

Microbial Pathogenesis
African Swine Fever (ASF) is an acute, highly contagious, and lethal disease caused by the African Swine Fever Virus (ASFV), posing a severe threat to the global pig farming industry. Although live vaccines are currently available, preventing and controlling ASF remains a considerable challenge.
Yuchen Zhang, Xiuzhen Mei, Chao Zhang, Hui Wang, Xing Xie, Zhenzhen Zhang, Zhixin Feng   +6 more
openaire   +2 more sources

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

2023
Abstract African swine fever (ASF) is an infectious disease characterized by hemorrhagic fever, highly pathogenic, and severe mortality in domestic pigs caused by the African swine fever virus (ASFV). ASFV is a large DNA virus and primarily infects porcine monocyte macrophages.
Keshan Zhang, Yu Hao, Bo Yang, Jinke Yang, Dajun Zhang, Xing Yang, Xijuan Shi, Dengshuai Zhao, Lingling Chen, Wenqian Yan, Yi Ru, Zixiang Zhu, Xiaodong Qin, Huanan Liu, Fan Yang, Dan Li, Hong Tian, Tao Feng, Jianhong Guo, Jijun He, Xiangtao Liu, Haixue Zheng   +21 more
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ASFV activates STAT3 to induce proviral M2 macrophage polarization

Veterinary Microbiology
African swine fever (ASF) is an acute and highly infectious disease caused by African swine fever virus (ASFV) that has dealt a massive blow to the development of the pig industry in China. Macrophages, the primary target cells of ASFV, exhibit high plasticity. However, their phenotypic changes during infection remain poorly understood.
Yanru Chen, Haowei Chen, Weijia Zhang, Penghao Lv, Zhichao Wang, Hanlin Liao, Kaiyue Wei, Qigai He, Min Cui   +8 more
openaire   +2 more sources

Evaluation of the Deletion of MGF110-5L-6L on Swine Virulence from the Pandemic Strain of African Swine Fever Virus and Use as a DIVA Marker in Vaccine Candidate ASFV-G-ΔI177L

Journal of Virology, 2022
Elizabeth Ramirez-Medina, Elizabeth Vuono, Ediane Silva   +2 more
exaly  

Development and application of a TaqMan-based real-time PCR method for the detection of the ASFV MGF505-7R gene

Frontiers in Veterinary Science, 2023
Yanxin Hu, Li Jinming, Ge Shengqiang
exaly  

Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV

Life, 2021
Xianfeng Hui, Xiaotong Hu, Meilin Jin
exaly  

ASFV transcription reporter screening system identifies ailanthone as a broad antiviral compound

Virologica Sinica, 2023
Yuhang Zhang, Dongming Zhao, Xiaofeng Zheng   +2 more
exaly  

Regulation of antiviral immune response by African swine fever virus (ASFV)

Virologica Sinica, 2022
Xiaojie Zheng, Wen-Hai Feng
exaly  

African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses

Vaccine, 2018
Carmina Gallardo, Elena G Sanchez, Daniel Pérez-Núñez   +2 more
exaly