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ASFV infection induces macrophage necroptosis and releases proinflammatory cytokine by ZBP1-RIPK3-MLKL necrosome activation [PDF]

Frontiers in Microbiology
African swine fever (ASF) is an infectious disease characterized by hemorrhagic fever, which is highly pathogenic and causes severe mortality in domestic pigs. It is caused by the African swine fever virus (ASFV).
Dajun Zhang, Yu Hao, Xing Yang, Xijuan Shi, Dengshuai Zhao, Lingling Chen, Huanan Liu, Zixiang Zhu, Haixue Zheng   +8 more
doaj   +2 more sources

Simultaneous ASFV and Haptoglobin Detection by Duplex qPCR Enables Pre-Viremia Diagnosis of African Swine Fever

Viruses
African swine fever (ASF), caused by African swine fever virus (ASFV), has inflicted severe economic losses on China’s pig industry. Existing ASFV nucleic acid detection methods struggle to identify infected pigs in the pre-viremic stage, especially for ...
Yun Bao, Shimin Gao, Shuang Li, Yijie Liu, Fei Gao, Liwei Li, Wu Tong, Changlong Liu, Yanjun Zhou, Yifeng Jiang   +9 more
doaj   +2 more sources

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine

Viruses, 2020
African swine fever virus (ASFV) is the causative agent of the African swine fever (ASF) epizootic currently affecting pigs throughout Eurasia, causing significant economic losses in the swine industry.
Elizabeth. Ramirez-Medina, Elizabeth. A. Vuono, Ayushi. Rai, Sarah. Pruitt, Ediane. Silva, Lauro. Velazquez-Salinas, James. Zhu, Manuel. V. Borca, Douglas. P. Gladue   +8 more
doaj   +1 more source

The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs

Emerging Microbes and Infections
African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control.
Yao Li, Yingnan Liu, Zhuyun Sun, Zhenhua Xie, Chuanwen Tian, Rongrong Wang, Jun Gao, Maomao Wang, Jingyi Liu, Heng Wang, Guihong Zhang, Jie Li, Dongdong Di, Lang Gong, Hongjun Chen   +14 more
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Identification of cepharanthine as an effective inhibitor of African swine fever virus replication

Emerging Microbes and Infections
African swine fever virus (ASFV) causes highly contagious swine disease, African swine fever (ASF), thereby posing a severe socioeconomic threat to the global pig industry and underscoring that effective antiviral therapies are urgently required.
Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang, Yingjuan Qian   +10 more
doaj   +1 more source

Kinetics of Viral Genome Distribution in Swine Peripheral Lymphoid Organs Following Oronasal Infection with Attenuated African swine fever virus strains

Viruses
African swine fever (ASF) continues to spread across the globe, causing a severe impact on the swine industry. Passive surveillance based on testing dead pigs is one of the most effective methods for early detection of ASF incursions.
Kalhari Goonewardene, Carissa Embury-Hyatt, Estella Moffat, Aruna Ambagala   +3 more
doaj   +1 more source

The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

mBio
Multigene family (MGF) 360 genes, which are African swine fever virus (ASFV) virulence genes, primarily target key host immune molecules to suppress host interferon (IFN) production and interferon-stimulated gene (ISG) transcription, impairing host ...
Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu   +13 more
doaj   +1 more source

African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assembly

Journal of Virology
African swine fever virus (ASFV) is the pathogen of African swine fever (ASF), and its infection causes a lethal disease in pigs, with severe pathological lesions.
Pan-Xue Wu, Wen-Ping Yang, Tao Feng, Jing Zhang, Guo-Qiang Zhu, Xu-Guang Du, Yi Ru, Yao-Feng Zhao, Sen Wu, Dan Li, Hai-Xue Zheng   +10 more
doaj   +1 more source

The antibodies against the A137R protein drive antibody-dependent enhancement of African swine fever virus infection in porcine alveolar macrophages

Emerging Microbes and Infections
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly contagious disease that can kill up to 100% of domestic pigs and wild boars.
Xiaoke Yang, Encheng Sun, Huanjie Zhai, Tao Wang, Shida Wang, Yuxuan Gao, Qinghe Hou, Xiangyu Guan, Shuwen Li, Lian-Feng Li, Hongxia Wu, Yuzi Luo, Su Li, Yuan Sun, Dongming Zhao, Yongfeng Li, Hua-Ji Qiu   +16 more
doaj   +1 more source

ASFV Proteins Presented at the Surface of T7 Phages Induce Strong Antibody Responses and Immune Cell Proliferation in Sus scrofa

Vaccines
Background/Objectives: African swine fever (ASF) causes massive global swine industry losses with no effective vaccine available. This study constructed T7 phages displaying key ASFV proteins to evaluate their potential as an ASF vaccine by assessing ...
Xinyi Zhang, Yingju Xia, Cheng Wang, Yan Li, Zhifei Li, Lu Xu, Junjie Zhao, Zhen Wang, Xingqi Zou, Xinyv Song, Yuanyuan Zhu, Jinhai Huang, Yebing Liu   +12 more
doaj   +1 more source