Results 1 to 10 of about 11,516 (233)

Interactome between ASFV and host immune pathway proteins

open access: yesmSystems, 2023
African swine fever virus (ASFV) causes severe acute hemorrhagic disease with high mortality in domestic pigs but minimal or no symptoms to warthogs, for which the underlying mechanism remains elusive.
Qijun Wu   +13 more
doaj   +5 more sources

Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L

open access: yesViruses, 2022
African swine fever (ASF) is the cause of a recent pandemic that is posing a threat to much of the world swine production. The etiological agent, ASF virus (ASFV), infects domestic and wild swine, producing a variety of clinical presentations depending ...
Cyril Gay, Douglas P. Gladue, Ayushi Rai
exaly   +6 more sources

ASFV-G-∆I177L as an Effective Oral Nasal Vaccine Against the Eurasia Strain of Africa Swine Fever

open access: yesViruses, 2021
The African swine fever virus (ASFV) is currently causing a pandemic affecting wild and domestic swine from Western Europe to Asia. No commercial vaccines are available to prevent African swine fever (ASF), resulting in overwhelming economic losses to ...
Elizabeth Ramirez-Medina   +2 more
exaly   +5 more sources

Structures and Functional Diversities of ASFV Proteins [PDF]

open access: yesViruses, 2021
African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a highly contagious double-stranded DNA virus. Its genome is in the range of 170~193 kbp and encodes 68 structural proteins and over 100 non-structural proteins.
Zhongzhou Chen
exaly   +5 more sources

Genotype II Live-Attenuated ASFV Vaccine Strains Unable to Completely Protect Pigs Against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam

open access: yesVaccines
Background: African swine fever virus (ASFV) continues to spread globally, causing severe economic losses to pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF to control the ongoing ASF ...
Nguyen Van Diep   +2 more
exaly   +3 more sources

Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses.

open access: yesJournal of Virology, 2023
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and acute hemorrhagic viral disease of domestic pigs, with a high mortality approaching 100%.
Zhigao Bu, Ye Guangqiang, Chunying Feng
exaly   +4 more sources

African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective Against Homologous Virulent Challenge

open access: yesViruses, 2023
ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection against challenges with the parental virus, the Georgia 2010 isolate, as well as against field strains isolated from Vietnam. ASFV-G-ΔI177L has been shown
Elizabeth Ramirez-Medina   +2 more
exaly   +4 more sources

Development and Application of a TaqMan-Based Real-Time PCR Method for the Detection of the ASFV MGF505-7R Gene

open access: yesFrontiers in Veterinary Science, 2023
African swine fever virus (ASFV), the etiological agent of African swine fever (ASF), causes deadly hemorrhagic fever in domestic pigs. ASF's high mortality and morbidity have had disastrous effects on the world's swine industry.
Shengqiang Ge, Chuanxiang Qi, Yongxin Hu
exaly   +2 more sources

Unamplified System for Sensitive and Typing Detection of ASFV by the Cascade Platform That CRISPR-Cas12a Combined With Graphene Field-Effect Transistor

open access: yesBiosensors and Bioelectronics, 2023
At present, the 100% case fatality and the cross-infection of virus strains make the ASFV 's harm to society continue to expand. The absence of an effective commercial vaccine poses early detection remains the most effective means of curbing ASFV ...
Lei Chen, Shuo Chen
exaly   +2 more sources

ASFV Transcription Reporter Screening System Identifies Ailanthone as a Broad Antiviral Compound

open access: yesVirologica Sinica, 2023
African swine fever (ASF) is an acute, highly contagious and deadly viral disease in swine that jeopardizes the worldwide pig industry. Unfortunately, there are no authoritative vaccine and antiviral drug available for ASF control.
Dongming Zhao, Nianchao Qian, Xu Tan
exaly   +2 more sources

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