Results 31 to 40 of about 5,108 (173)

Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

Pathogens, 2020
This paper was aimed to characterize clinical signs and pathomorphological lesions in twenty-two pigs, infected intranasally by different doses of African swine fever virus (Pol18_28298_O111), isolated during the outbreak in a pig farm that occurred in ...
Marek Walczak, Jacek Żmudzki, Natalia Mazur-Panasiuk, Małgorzata Juszkiewicz, Grzegorz Woźniakowski   +4 more
doaj   +1 more source

Novel mechanism of African swine fever virus protein regulating typeⅡinterferon signaling pathway

生物医学转化, 2022
African swine fever virus (ASFV) is a large DNA virus that is highly contagious and pathogenic in domestic pigs with a mortality rate up to 100%. However, how ASFV suppresses JAK-STAT1 signaling to evade the immune response remains unclear. In this study,
Zhang Jing, Li Dan, Zheng Haixue
doaj   +1 more source

Comparison of Macrophage Responses to African Swine Fever Viruses Reveals that the NH/P68 Strain is Associated with Enhanced Sensitivity to Type I IFN and Cytokine Responses from Classically Activated Macrophages

Pathogens, 2020
African swine fever (ASF) poses a severe threat to the global pig industry for which currently there is no available vaccine. The aetiological ASF virus (ASFV) has a predilection for cells of the myeloid lineage, however little is known about its ...
Giulia Franzoni, Elisabetta Razzuoli, Silvia Dei Giudici, Tania Carta, Grazia Galleri, Susanna Zinellu, Mauro Ledda, Pierpaolo Angioi, Paola Modesto, Simon P. Graham, Annalisa Oggiano   +10 more
doaj   +1 more source

Identification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein

Drug Delivery, 2021
The African swine fever virus (ASFV) is a huge and complex DNA virus that can lead to the acute death of pigs and cause huge losses to the global swine industry.
Shunli Yang, Xinming Zhang, Yuying Cao, Shuo Li, Junjun Shao, Shiqi Sun, Huichen Guo, Shuanghui Yin   +7 more
doaj   +1 more source

Meat Exudate for Detection of African Swine Fever Virus Genomic Material and Anti-ASFV Antibodies

Viruses, 2021
African swine fever (ASF) is one of the most important viral diseases of pigs caused by the ASF virus (ASFV). The virus is highly stable over a wide range of temperatures and pH and can survive in meat and meat products for several months, leading to ...
Chukwunonso Onyilagha, Mikyla Nash, Orlando Perez, Melissa Goolia, Alfonso Clavijo, Juergen A. Richt, Aruna Ambagala   +6 more
doaj   +1 more source

A blocking ELISA based on virus-like nanoparticles chimerized with an antigenic epitope of ASFV P54 for detecting ASFV antibodies

Scientific Reports, 2023
AbstractAfrican swine fever virus (ASFV) is a highly lethal pathogen of domestic and wild pigs. Due to no vaccines or drugs available, early accurate diagnosis and eradication of infected animals are the most important measures for ASFV prevention and control.
Chaohua Huang, Chenfu Cao, Zhichao Xu, Yanxing Lin, Jiang Wu, Qiaoyu Weng, Zheng Liu, Ye Jin, Peng Chen, Qunyi Hua   +9 more
openaire   +3 more sources

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

mBio, 2022
African swine fever (ASF)—an aggressive infectious disease caused by the African swine fever virus (ASFV)—is significantly unfavorable for swine production. ASFV has a complex structure and encodes 150–167 proteins; however, the function of most of these
Keshan Zhang, Bo Yang, Chaochao Shen, Ting Zhang, Yu Hao, Dajun Zhang, Huanan Liu, Xijuan Shi, Guoli Li, Jinke Yang, Dan Li, Zixiang Zhu, Hong Tian, Fan Yang, Yi Ru, Wei Jun Cao, Jianhong Guo, Jijun He, Haixue Zheng, Xiangtao Liu   +19 more
doaj   +1 more source

The 24.5-kb Left Variable Region Is Not a Determinant for African Swine Fever Virus to Replicate in Primary Porcine Alveolar Macrophages

Viruses, 2022
African swine fever (ASF) is a widespread hemorrhagic and highly contagious infectious disease caused by African swine fever virus (ASFV), currently threatening the pig industry worldwide. Here, we demonstrated that the cell-adapted strain ASFV-P121 with
Rui Luo, Tao Wang, Maowen Sun, Li Pan, Shujian Huang, Yun Sun, Hua-Ji Qiu   +6 more
doaj   +1 more source

The attenuated ASFV strains MK-200 and FK-32/135 as possible models for investigation of protective immunity by ASFV infection

PLOS ONE, 2022
African swine fever (ASF) is an infectious disease of domestic and wild pigs of all breeds and ages, with the acute form of the disease being characterized by high fever, hemorrhages in the reticuloendothelial system and a high mortality rate. Registered safe and efficacious ASF vaccines are not available.
Alexey D. Sereda, Anna S. Kazakova, Sanzhi G. Namsrayn, Mikhail E. Vlasov, Denis V. Kolbasov   +4 more
openaire   +3 more sources

Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis

Virology Journal, 2023
Background African swine fever virus (ASFV) is one of the most fatal swine etiological agents and has a huge economic impact on the global pork industry. Given that no effective vaccines or anti-ASFV drugs are available, there remains a pressing need for
Yang Chen, Yanchen Guo, Hao Chang, Zebu Song, Zhi Wei, Zhao Huang, Zezhong Zheng, Guihong Zhang, Yankuo Sun   +8 more
doaj   +1 more source