Results 31 to 40 of about 11,516 (233)

ASFV Proteins Presented at the Surface of T7 Phages Induce Strong Antibody Responses and Immune Cell Proliferation in Sus scrofa

Vaccines
Background/Objectives: African swine fever (ASF) causes massive global swine industry losses with no effective vaccine available. This study constructed T7 phages displaying key ASFV proteins to evaluate their potential as an ASF vaccine by assessing ...
Xinyi Zhang, Yingju Xia, Cheng Wang, Yan Li, Zhifei Li, Lu Xu, Junjie Zhao, Zhen Wang, Xingqi Zou, Xinyv Song, Yuanyuan Zhu, Jinhai Huang, Yebing Liu   +12 more
doaj   +2 more sources

Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged With the Virulent African Swine Fever Virus Field Isolate Georgia 2010

Pathogens
We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G).
Elizabeth Ramirez-Medina, Edward J Spinard, Douglas P. Gladue   +2 more
exaly   +3 more sources

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence-Associated Factor pMGF300-2R. [PDF]

Adv Sci (Weinh)
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Luo R, Zhang J, Huang R, Zhang X, Li LF, Lan J, Lu Z, Sun Y, Wang T, Qiu HJ.   +9 more
europepmc   +2 more sources

A review of some important viral diseases of wild boars [PDF]

Biotechnology in Animal Husbandry, 2021
Wild boars are one of the widest-ranging mammals worldwide and represent reservoirs for many important viruses. Disease outbreaks in domestic swine are often described as a consequence of contact with wild boars, and traditional rearing conditions are a ...
Nišavić Jakov, Radalj Andrea, Milić Nenad, Živulj Aleksandar, Benković Damir, Stanojković Aleksandar, Prošić Isidora   +6 more
doaj   +1 more source

Expression of a recombinant ASFV P30 protein and production of monoclonal antibodies

Open Veterinary Journal, 2023
Background: African Swine Fever (ASF) is an infectious disease that affects domestic pig and wild boar populations. The African Swine Fever Virus (ASFV) has a genome characterized by a very complex DNA (170-193 kb) that encodes for more than 200 ...
Rosrio Liberti, Claudia Colabella, Lucia Anzalone, Giulio Severi, Antonella Di Paolo, Cristina Casciari, Anna Beatrice Casano, Monica Giammarioli, Monica Cagiola, Francesco Feliziani, Antonio De Giuseppe   +10 more
doaj   +1 more source

Patterns of ASFV Transmission in Domestic Pigs in Serbia [PDF]

Pathogens, 2023
The first case of African swine fever in domestic pigs in Serbia was in 2019. The following year, the disease was confirmed in wild boar. Thenceforth, ASF has been continuously reported in both wild and domestic pigs. The outbreaks in domestic pigs could not be linked directly to wild boars, even though wild boars were endemically infected, and ...
Dimitrije Glišić, Vesna Milićević, Ljubiša Veljović, Bojan Milovanović, Branislav Kureljušić, Igor Đorđević, Katarina Anđelković, Jelena Petković, Miroljub Dačić   +8 more
openaire   +4 more sources

Inhibition of African swine fever virus replication by β-glucan

Open Veterinary Journal, 2022
Background: African swine fever (ASF) is one of the most important diseases in pigs because of its effects on all ages and breeds. To date, the commercial vaccines and drugs for prevention of ASF are lacking in the market and the survival of ASFV in ...
Truong Anh Duc, Ha Thi Thanh Tran, Nhu Thi Chu, Huyen Thi Nguyen, Hoang Vu Dang, Nam Hoai Vu, Hans Lee, Fatimah Siti, Tinh Nguyen, Alexander de Leon, Andrew G Yersin   +10 more
doaj   +1 more source

Genotype II Live-Attenuated ASFV Vaccine Bearing 24 Genes Deletion in 3 Independent Regions Is Able to Provide Complete Protection Against Homologous Lethal Challenge. [PDF]

FASEB J
African swine fever (ASF) is a highly contagious and lethal viral disease of swine. Therefore, it is urgent to develop a safe and effective vaccine. We constructed a live‐attenuated ASF vaccine bearing 24 gene deletions in 3 independent regions, ASFV‐Δ24.
Xu F, Dang W, Du Y, Li T, Liu H, Shi Z, Tian H, He J, Zheng H.   +8 more
europepmc   +2 more sources

Transcriptomic and Metabolomic Profiling Identifies a Core Gene-Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis. [PDF]

FASEB J
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Luo J, Guo K, Xiao F, Wang R, Guo J, Ren Q, Zhao S, Obaid MK, Guan G, Yin H.   +9 more
europepmc   +2 more sources

The Structure of ASFV Advances the Fight against the Disease [PDF]

Trends in Biochemical Sciences, 2020
African swine fever virus (ASFV) is the causative pathogen of the recent African swine fever epidemic, with devastating impacts on economy. A recent study by Wang et al. reveals the multilayer structural details of ASFV at near-atomic resolution, which provides interesting insights about giant virus assembly and paves the way for vaccine development.
Yuejiao, Xian, Chuan, Xiao
openaire   +2 more sources