Results 21 to 30 of about 9,741 (217)

African Swine Fever Virus (ASFV): Immunity and Vaccine Development

Vaccines, 2023
African swine fever virus (ASFV) is the causative agent of the highly contagious disease African swine fever (ASF), which can result in mortality rates of up to 100% in pigs infected by virulent strains [...]
Kiramage Chathuranga, Jong-Soo Lee
openaire   +3 more sources

The 24.5-kb Left Variable Region Is Not a Determinant for African Swine Fever Virus to Replicate in Primary Porcine Alveolar Macrophages

Viruses, 2022
African swine fever (ASF) is a widespread hemorrhagic and highly contagious infectious disease caused by African swine fever virus (ASFV), currently threatening the pig industry worldwide. Here, we demonstrated that the cell-adapted strain ASFV-P121 with
Rui Luo, Tao Wang, Maowen Sun, Li Pan, Shujian Huang, Yun Sun, Hua-Ji Qiu   +6 more
doaj   +1 more source

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

mBio, 2022
African swine fever (ASF)—an aggressive infectious disease caused by the African swine fever virus (ASFV)—is significantly unfavorable for swine production. ASFV has a complex structure and encodes 150–167 proteins; however, the function of most of these
Keshan Zhang, Bo Yang, Chaochao Shen, Ting Zhang, Yu Hao, Dajun Zhang, Huanan Liu, Xijuan Shi, Guoli Li, Jinke Yang, Dan Li, Zixiang Zhu, Hong Tian, Fan Yang, Yi Ru, Wei Jun Cao, Jianhong Guo, Jijun He, Haixue Zheng, Xiangtao Liu   +19 more
doaj   +1 more source

Host Responses to Live-Attenuated ASFV (HLJ/18–7GD)

Viruses, 2022
African swine fever (ASF) is a highly contagious and fatal disease caused by the African swine fever virus. Recently, the multigene family and CD2v gene-deleted ASF vaccine candidate HLJ/18-7GD was found to be safe and effective in laboratory and clinical trials.
Yuqin Fan, Weiye Chen, Chenggang Jiang, Xianfeng Zhang, Ying Sun, Renqiang Liu, Jingfei Wang, Decheng Yang, Dongming Zhao, Zhigao Bu, Xijun He   +10 more
openaire   +3 more sources

Transmission routes of African swine fever virus to domestic pigs: current knowledge and future research directions [PDF]

, 2016
African swine fever (ASF) is a major threat to the pig industry in Europe. Since 2007, ASF outbreaks have been ongoing in the Caucasus, Eastern Europe and the Baltic countries, causing severe economic losses for many pig farmers and pork producers.
BALDACCHINO, BLOME, BOINAS, COSTARD, DAVIES, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DIAZ, EC, EC, EC, EC, EC, EFSA, EU, FAO, FAO, GABRIEL, GALLARDO, GALLARDO, GALLARDO, GOGIN, GREIG, GREIG, GUINAT, GUINAT, GULENKIN, HAAS, HEUSCHELE, HOWEY, IGLESIAS, KAGIRA, LANGE, MANZANO-ROMÁN, MCKERCHER, MCVICAR, MEBUS, MEBUS, MELLOR, MONTGOMERY, OGANESYAN, OIE, PARKER, PHENGSAVANH, PIETSCHMANN, PLOWRIGHT, PLOWRIGHT, PLOWRIGHT, ROWLANDS, SANCHEZ BOTIJA, SANCHEZ BOTIJA, SODEIKAT, THOMSON, THURFJELL, TURNER, VERGNE, VERGNE, VLASOVA, WILKINSON   +60 more
core   +2 more sources

Dynamics of African swine fever virus (ASFV) infection in domestic pigs infected with virulent, moderate virulent and attenuated genotype II ASFV European isolates. [PDF]

Transboundary and Emerging Diseases, 2021
This study aimed to compare the infection dynamics of three genotype II African swine fever viruses (ASFV) circulating in Europe. Eighteen domestic pigs divided into three groups were infected intramuscularly or by direct contact with two haemadsorbent ASFVs (HAD) from Poland (Pol16/DP/ OUT21) and Estonia (Est16/WB/Viru8), and with the Latvian non-HAD ...
Carmina Gallardo, Alejandro Soler, Imbi Nurmoja, Cristina Cano‐Gómez, Svetlana Cvetkova, Maciej Frant, Grzegorz Woźniakowski, Alicia Simón, Covadonga Pérez, Raquel Nieto, Marisa Arias   +10 more
openaire   +3 more sources

Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis

Virology Journal, 2023
Background African swine fever virus (ASFV) is one of the most fatal swine etiological agents and has a huge economic impact on the global pork industry. Given that no effective vaccines or anti-ASFV drugs are available, there remains a pressing need for
Yang Chen, Yanchen Guo, Hao Chang, Zebu Song, Zhi Wei, Zhao Huang, Zezhong Zheng, Guihong Zhang, Yankuo Sun   +8 more
doaj   +1 more source

Dynamics of African swine fever virus shedding and excretion in domestic pigs infected by intramuscular inoculation and contact transmission [PDF]

, 2014
African swine fever virus (ASFV) is a highly virulent swine pathogen that has spread across Eastern Europe since 2007 and for which there is no effective vaccine or treatment available.
Dixon, L, Goatley, L, Guinat, C, Netherton, C L, Pfeiffer, D U, Pirbright, Reis, A L   +6 more
core   +5 more sources

The MGF360-16R ORF of African Swine Fever Virus Strain Georgia Encodes for a Nonessential Gene That Interacts with Host Proteins SERTAD3 and SDCBP

Viruses, 2020
African swine fever virus (ASFV) causes a contagious and frequently lethal disease of pigs with significant economic consequences to the swine industry.
Elizabeth Ramírez-Medina, Elizabeth A. Vuono, Lauro Velazquez-Salinas, Ediane Silva, Ayushi Rai, Sarah Pruitt, Keith A. Berggren, James Zhu, Manuel V. Borca, Douglas P. Gladue   +9 more
doaj   +1 more source

Evaluation of the Function of ASFV Gene E66L in the Process of Virus Replication and Virulence in Swine

Viruses, 2023
African swine fever virus (ASFV) is the etiological agent of an economically important disease of swine currently affecting large areas of Africa, Eurasia and the Caribbean.
Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Ayushi Rai, Nallely Espinoza, Alyssa Valladares, Edward Spinard, Lauro Velazquez-Salinas, Douglas P. Gladue, Manuel V. Borca   +8 more
doaj   +1 more source