CD1D knockout swine are permissive to African swine fever virus genotype II infection [PDF]
Emerging Microbes and InfectionsAfrican swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ...
Daniel Madden +15 more
doaj +2 more sources
Reclassification of ASFV into 7 Biotypes Using Unsupervised Machine Learning
Viruses, 2023 In 2007, an outbreak of African swine fever (ASF), a deadly disease of domestic swine and wild boar caused by the African swine fever virus (ASFV), occurred in Georgia and has since spread globally.
Douglas P. Gladue +8 more
core +4 more sources
ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
Viruses, 2021 The African swine fever virus (ASFV) is currently causing a pandemic affecting wild and domestic swine from Western Europe to Asia. No commercial vaccines are available to prevent African swine fever (ASF), resulting in overwhelming economic losses to ...
Elizabeth Ramirez-Medina +2 more
exaly +3 more sources
VaccinesBackground/Objectives: African Swine Fever (ASF) represents one of the most serious threats to animal health and global food security. The causative agent of ASF is the African swine fever virus (ASFV), a DNA virus belonging to the Asfarviridae family ...
Flavia Ferrantelli +11 more
core +2 more sources
Emergence of Non-Hemadsorbing African Swine Fever Virus Genotype II Variants and the Evolution of a Vaccine-Derived Strain in Vietnam [PDF]
VirusesHighly virulent African swine fever virus (ASFV) genotype II strains have been responsible for the global epidemic in domestic pigs and are typically characterized by a hemadsorption (HAD)-positive phenotype mediated by the CD2v protein encoded by the ...
Thi Chau Giang Tran +11 more
doaj +2 more sources
Duration of immunity following infection with moderately virulent ASFV.
PLOS PathogensAfrican swine fever virus (ASFV) poses a significant threat to pork production and wild pig populations worldwide. The study assessed the long-term fate and immunity of animals recovering from a moderately virulent ASFV infection, following the ...
Sch\ue4fer, Alexander +13 more
core +4 more sources
Genotype II Live-Attenuated ASFV Vaccine Bearing 24 Genes Deletion in 3 Independent Regions Is Able to Provide Complete Protection Against Homologous Lethal Challenge. [PDF]
FASEB JAfrican swine fever (ASF) is a highly contagious and lethal viral disease of swine. Therefore, it is urgent to develop a safe and effective vaccine. We constructed a live‐attenuated ASF vaccine bearing 24 gene deletions in 3 independent regions, ASFV‐Δ24.
Xu F +8 more
europepmc +2 more sources
PathogensWe have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G).
Edward Spinard +2 more
exaly +3 more sources
Transcriptomic and Metabolomic Profiling Identifies a Core Gene-Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis. [PDF]
FASEB JTranscriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Luo J +9 more
europepmc +2 more sources
A review of some important viral diseases of wild boars [PDF]
Biotechnology in Animal Husbandry, 2021 Wild boars are one of the widest-ranging mammals worldwide and represent reservoirs for many important viruses. Disease outbreaks in domestic swine are often described as a consequence of contact with wild boars, and traditional rearing conditions are a ...
Nišavić Jakov +6 more
doaj +1 more source