Results 71 to 80 of about 1,544,983 (360)

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher, Alexander Ankar, Jon Cokley, Eyal Muscal, James J. Riviello, Yi‐Chen Lai   +5 more
wiley   +1 more source

Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis

Frontiers in Cellular and Infection Microbiology, 2022
Disseminated coccidioidomycosis (DCM), often a severe and refractory disease leading to poor outcomes, is a risk for people with certain primary immunodeficiencies (PID).
Daniel A. Powell, Daniel A. Powell, Amy P. Hsu, Christine D. Butkiewicz, Hien T. Trinh, Jeffrey A. Frelinger, Steven M. Holland, John N. Galgiani, John N. Galgiani, Lisa F. Shubitz   +9 more
doaj   +1 more source

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam. [PDF]

, 2011
BACKGROUND: typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S.
Baker, Stephen, Campbell, James I, Chau, Tran Thuy, Dolecek, Christiane, Dougan, Gordon, Duy, Pham Thanh, Farrar, Jeremy, Hien, Tran Tinh, Hoang, Nguyen Van Minh, Holt, Kathryn E, La, Tran Thi Phi, Manh, Bui Huu, Nga, Tran Vu Thieu, Vinh Chau, Nguyen Van   +13 more
core   +1 more source

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin [PDF]

, 2020
Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD). The optimal dose of aspirin, however, remains
Belarski, Emily, Carroll, Aaron E., John, Chandy C., Manaloor, John, Ofner, Susan, Platt, Brooks, Wood, James B.   +6 more
core   +1 more source

Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS). Methods This single‐center, single‐blind, randomized trial enrolled infants aged 2–14 months with new‐onset IESS, randomly assigned them (1:1) to receive either
Rachata Boonkrongsak, Kantapon Trongkamolchai, Sirorat Suwannachote, Somjit Sri‐Udomkajorn, Raviwan Wittawassamrankul, Ravindra Arya, Kullasate Sakpichaisakul   +6 more
wiley   +1 more source

African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation

Veterinary Research
African swine fever virus (ASFV) is a DNA virus that has significantly impacted the global swine industry. Currently, there are no effective therapies or vaccines against ASFV.
Han Gao, Taoming Gu, Xiaopeng Gao, Zebu Song, Jing Liu, Yi Song, Guihong Zhang, Yankuo Sun   +7 more
doaj   +1 more source

Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus

Viruses, 2020
This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high capacity for virus trans-placental transmission as ...
Miaomiao Wang, Enrica Sozzi, José Alejandro Bohórquez, Mònica Alberch, Joan Pujols, Guillermo Cantero, Alessandra Gaffuri, Davide Lelli, Rosa Rosell, Albert Bensaid, Mariano Domingo, Lester Josue Pérez, Ana Moreno, Llilianne Ganges   +13 more
doaj   +1 more source

Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential [PDF]

, 2016
The appearance of novel pathogens of humans with epidemic potential and high mortality rates have threatened global health security for centuries. Over the past few decades new zoonotic infectious diseases of humans caused by pathogens arising from ...
Abdulaziz N. Alagaili, Alagaili, Alimuddin Zumla, Arabi, Arabi, Azhar, Briese, Du, Esam I. Azhar, Eskild Petersen, Francine Ntoumi, Giuseppe Ippolito, Gossner, Haagmans, Hui, Hui, Ippolito, Jacobsen, Macete Eusebio, Markus Maeurer, Mathis, Matthew Bates, Matthew Cotten, Matthew Muturi, McCloskey, Memish, Mishal Khan, Mohd, Osman Dar, Peiris, Peter Mwaba, Petersen, Petersen, Pontiano Kaleebu, Rashid Ansumana, Reusken, Richard Kock, Sabir, Sayoki Mfinanga, Smith, The, Thiam, Uyeki, Wang, Zaki, Zumla, Zumla, Zumla   +47 more
core   +6 more sources

A Multi-Level Attention Model for Evidence-Based Fact Checking [PDF]

arXiv, 2021
Evidence-based fact checking aims to verify the truthfulness of a claim against evidence extracted from textual sources. Learning a representation that effectively captures relations between a claim and evidence can be challenging. Recent state-of-the-art approaches have developed increasingly sophisticated models based on graph structures.
arxiv  

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source