Results 31 to 40 of about 738 (107)

Safety and Drug–Drug Interaction Burden of Direct‐Acting Antiviral Therapy for Hepatitis C: A Single‐Center Community Hospital Analysis

International Journal of Hepatology, Volume 2026, Issue 1, 2026.
Background Polypharmacy leads to drug–drug interactions (DDIs) with direct‐acting antivirals (DAAs). We quantified the DDI burden (Liverpool categories) and evaluated its association with effectiveness and safety. We assessed renal function as a predictor of adverse events (AEs) and reported loss to follow‐up (LTFU). Methods We retrospectively analyzed
Satoru Okabe, Akira Doi, Kengo Matsumoto, Masashi Yamamoto, Koji Fukui, Tsutomu Nishida, Sreeja Dattachoudhury   +6 more
wiley   +1 more source

Indoor VOC Filtration Mitigates Pulmonary Inflammation in Murine Models of Allergic Asthma and LPS‐Induced Acute Lung Injury

Indoor Air, Volume 2026, Issue 1, 2026.
Indoor volatile organic compounds (VOCs) are ubiquitous and often within guideline ranges, yet their impact on allergic lung disease and pharmacologic responses remains unclear. We tested whether lowering VOCs attenuates lung inflammation and modifies antihistamine efficacy in murine asthma and acute lung injury (ALI) models, and related these findings
Kengo Tomita, Chiharu Ohira, Mao Kaneki, Yukiko Ota, Keiichi Yano, Mona Amano, Masaki Nagane, Satoshi Takagi, Tomoki Fukuyama, Evandro Eduardo Broday   +9 more
wiley   +1 more source

Comparative efficacy of oral fexofenadine hydrochloride and intranasal fluticasone furoate in patients with moderate to severe allergic rhinitis: A prospective randomized comparative study.

Student's Journal of Health Research Africa
Background Allergic rhinitis (AR) is a prevalent chronic condition with a significant impact on quality of life. Pharmacotherapy with non-sedating antihistamines and intranasal corticosteroids remains the mainstay, though comparative evidence in Indian ...
Dr. Praneeth Kumar K, Dr. N Chetan Rahul, Dr. Narendrula Srilekha, Dr. Mohd Abdul Nihal   +3 more
doaj   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li, Fangfang Li, Yang Tang, Siyu Guo, Yihan Yao, Yuan Fang, Bicheng Zhang, Yu Jiang, Jing Wang, Dang Wu, Jianxia Cheng, Zhihui Huang, Zengfeng Xin, Ting Zhang   +13 more
wiley   +1 more source

Enantiocomplementary Bioreduction of Flexible Ring N‐(3‐Oxobutyl)Heterocycles Providing Enantiopure Chiral Fragments for Drug Discovery

ChemBioChem, Volume 26, Issue 19, October 3, 2025.
Bioreduction of flexible ring N‐(3‐oxobutyl)‐heterocycles mediated by enantiocomplementary recombinant alcohol dehydrogenases [an (S)‐selective one from Rhodococcus aetherivorans (RaADH), and an (R)‐selective one from Lactobacillus kefir (LkADH)], as whole‐cell biocatalysts results in enantiopure (S)‐ and (R)‐alcohols (ee > 99%), which are promising ...
Máté Gergő Honvári, Levente András Mócza, Bence Attila Kucsinka, Pál Csuka, Viktória Bódai, Diana Maria Scrob, László Poppe, Gábor Hornyánszky   +7 more
wiley   +1 more source

A Randomized Control Trail of Stepwise Treatment with Fluticasone Propionate Nasal Spray and Fexofenadine Hydrochloride Tablet for Seasonal Allergic Rhinitis

Allergology International, 2012
Background: In Japan, oral antihistamines are frequently used as the initial treatment for seasonal allergic rhinitis (SAR), and intranasal steroids are added when nasal symptoms worsen.
Goro Takahashi, Zensei Matsuzaki, Atsushi Okamoto, Eiko Ito, Tomokazu Matsuoka, Takeo Nakayama, Keisuke Masuyama   +6 more
doaj   +1 more source

The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose‐Dependent: A Three‐Arm Crossover Study in Adults With Type 2 Diabetes

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Pharmacokinetic drug interactions can lead to unexpected changes in plasma concentrations of the object drug, potentially increasing the risk for adverse effects and/or decreasing therapeutic efficacy. The botanical product goldenseal was previously shown to decrease metformin systemic exposure in healthy adults.
James T. Nguyen, Christopher M. Arian, Rakshit S. Tanna, Maxey G. Cherel, Matthew E. Layton, John R. White, Kenneth E. Thummel, Mary F. Paine   +7 more
wiley   +1 more source

“Shortening time to pregnancy in infertile women by personalizing treatment of microbial imbalance through Emma & Alice: A multicenter prospective study”

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
This study evaluated the effect of endometrial microbiome analysis (EMMA & ALICE) on pregnancy outcomes in women with RIF or RPL. The dysbiosis group treated with antibiotics and probiotics achieved significantly faster pregnancies compared to the normal group, suggesting that addressing uterine dysbiosis may shorten the time to pregnancy.
Nanako Iwami, Shinnosuke Komiya, Yoshimasa Asada, Kenichi Tatsumi, Toshihiro Habara, Takeshi Kuramoto, Moritoshi Seki, Hiroaki Yoshida, Kazuhiro Takeuchi, Masahide Shiotani, Tetsunori Mukaida, Yasushi Odawara, Yasuyuki Mio, Hirobumi Kamiya   +13 more
wiley   +1 more source

Therapeutic effect of bilastine in Japanese cedar pollinosis using an artificial exposure chamber (OHIO Chamber)

Allergology International, 2017
Background: Environmental exposure chambers have been used to expose subjects to aeroallergens to investigate the efficacy of prophylactic treatment with symptomatic agents in Japan.
Kazuhiro Hashiguchi, Ken-ichiro Wakabayashi, Michinori Togawa, Akihiro Saito, Kimihiro Okubo   +4 more
doaj   +1 more source

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton, Michael R. Gionfriddo, Gail B. Rattinger, Yuan Fang, Mia E. Lussier   +4 more
wiley   +1 more source