Results 51 to 60 of about 1,100,706 (301)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Study of the bijective relationship between the single and bundle cotton fiber mechanical properties [PDF]
, 2017 The characterization of cotton fiber is very complex due to the growing and harvesting conditions of the cotton plant. It is very important for breeders to understand the relationships that may exist between specific fiber properties, overall fiber ...
Dréan, Jean-Yves +4 more
core
Development of polymeric hollow fiber membranes containing catalytic metal nanoparticules. [PDF]
, 2010 Metal nanoparticles (MNPs) have unique physico-chemical properties advantageous for catalytic applications which differ from bulk material. However, the main drawback of MNPs is their insufficient stability due to a high trend for aggregation.
Bruening, Merlin L. +5 more
core +4 more sources
BiologyCotton is a globally significant economic crop. Brassinosteroids (BRs) are crucial to cotton development. This study systematically analyzed the BR synthase gene family in four cotton species and identified 60 BR genes: 20 in Gossypium hirsutum (GhBRs ...
Shiyan Cui +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Frontiers in Plant Science, 2019 Crop domestication from wild ancestors has resulted in the wide adaptation coupled with improved yield and quality traits. However, the genetic basis of many domesticated characteristics remains to be explored.
Guozhong Zhu +6 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Development of fiber shields for engine containment [PDF]
, 1977 Tests were conducted in translational launchers and spin pits to generate empirical data used in the design of a Kevlar shield for containing engine burst debris.
Bristow, R. J., Davidson, C. D.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Bidirectional link mock-up for avionics applications [PDF]
, 2008 Copper-based networks have been extensively employed on aircraft to ensure the avionics data-communications. Since the Airbus A380 development, Avionic Data Communication Network (ADCN) has been implemented to ensure transmissions between avionic ...
A. Rissons +5 more
core +1 more source