Results 71 to 80 of about 16,853,105 (384)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Genetic Basis of Fiber Improvement and Decreased Stress Tolerance in Cultivated Versus Semi-Domesticated Upland Cotton

Frontiers in Plant Science, 2019
Crop domestication from wild ancestors has resulted in the wide adaptation coupled with improved yield and quality traits. However, the genetic basis of many domesticated characteristics remains to be explored.
Guozhong Zhu, Weixi Li, Guilin Wang, Lechen Li, Qingxin Si, Caiping Cai, Wangzhen Guo   +6 more
doaj   +1 more source

Study of the bijective relationship between the single and bundle cotton fiber mechanical properties [PDF]

, 2017
The characterization of cotton fiber is very complex due to the growing and harvesting conditions of the cotton plant. It is very important for breeders to understand the relationships that may exist between specific fiber properties, overall fiber ...
Dréan, Jean-Yves, Gourlot, Jean-Paul, Harzallah, Omar, Mahjoub, Wafa, Segovia, César   +4 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Development of fiber shields for engine containment [PDF]

, 1977
Tests were conducted in translational launchers and spin pits to generate empirical data used in the design of a Kevlar shield for containing engine burst debris.
Bristow, R. J., Davidson, C. D.
core   +1 more source

Tensile testing of cellulose based natural fibers for structural composite applications [PDF]

, 2009
A series of tensile tests were conducted on a Lloyd LRX tensile testing machine for numerous natural fibers deemed potential candidates for development in composite applications.
Anthony Kelly, Bledzki, A.K., Borysiak, S., Eichhorn, S.J., Franck, Robert R., Geethamma, V.G., Mark C. Symington, Murali Mohan Rao, K., Olesen, P.O., Opukuro David West, Panigrahi, S., R.A. Pethrick, W.M. Banks   +12 more
core   +2 more sources

Characterization of bHLH/HLH genes that are involved in brassinosteroid (BR) signaling in fiber development of cotton (Gossypium hirsutum)

BMC Plant Biology, 2018
Basic helix-loop-helix/helix-loop-helix (bHLH/HLH) transcription factors play important roles in plant development. Many reports have suggested that bHLH/HLH proteins participate in brassinosteroid (BR) hormone signaling pathways to promote cell ...
Rui Lu, Jiao Zhang, Dong Liu, Ying-Li Wei, Yao Wang, Xue-Bao Li   +5 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Developmental and hormonal regulation of fiber quality in two natural-colored cotton cultivars

Journal of Integrative Agriculture, 2017
: Cotton cultivars with brown (Xiangcaimian 2), green (Wanmian 39) and white (Sumian 9) fiber were investigated to study fiber developmental characteristics of natural-colored cotton and the effect of hormones on fiber quality at different stages after ...
Xiang ZHANG, Da-peng HU, Yuan LI, Yuan CHEN, Eltayib H.M.A. Abidallha, Zhao-di DONG, De-hua CHEN, Lei ZHANG   +7 more
doaj   +1 more source

Bidirectional link mock-up for avionics applications [PDF]

, 2008
Copper-based networks have been extensively employed on aircraft to ensure the avionics data-communications. Since the Airbus A380 development, Avionic Data Communication Network (ADCN) has been implemented to ensure transmissions between avionic ...
A. Rissons, E. Gambardella, F. Quentel, J.C. Mollier, K. S. Ly, M. Pez   +5 more
core   +1 more source