Results 131 to 140 of about 57,814 (332)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Perspective in next-generation home networks: Toward optical solutions? [PDF]

, 2010
Sylvain Meyer, M. BELLEC, P. GUIGNARD, Benoit Charbonnier, Martial Bellec, Noella Evanno, D. CARDENAS, Dieter Jager, S. MEYER, Philippe Guignard, Bellec, M., I. MÖLLERS, Cardenas, D., Evanno, N., Ingo Mollers, Roberto Gaudino, Charbonnier, B., Guignard, P., Meyer, S., Daniel Cardenas, N. EVANNO, Jäger, D., Anna Pizzinat, B. CHARBONNIER, Möllers, I., Gaudino, Roberto, D. JÄGER   +26 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

A glimmer of light in 'fiber' debate?

, 2005
Proposal to create nonprofit organization in lieu of city management of 'fiber to the home ...
Palo Alto Weekly
core  

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

ICE volume 44 issue 11 Cover and Front matter

Infection control and hospital epidemiology, 2023
Clostridioides difficile, colonization and the, frequency of, treatment for, G. Sanchez-García, María B Cortés-Lara, Pilar, Berdonces-Gonzalez, J. Maria, de Goikoetxea, Antoni Oliver, Satoshi Atsushi Saito, Takahashi, H． Chiba，, Traditional, definition of healthcare-associated, healthcare-associated, influenza underestimates, cases, with other, Healthcare, exposures in a population-based, population-based surveillance, System, Erin B. Gettler, H. Talbot, Yuwei Zhu Danielle, Edward Mitchel Ndi, Tiffanie M. Markus, William, B. Schaffner, H. Thomas, R. Talbot, Diagnostic Stewardship, to support, optimal use of multiplex, molecular respiratory panels, A. For, Healthcare, Epidemiology, O. Research, Network, Jonathan, D. Baghdadi, M. O'Hara, J. K. Johnson, Sarah L. Krein, D. Anthony, .. Harris, J. andDaniel, Morgan, exposures in, common, areas—Epidemiological and, whole-genome sequencing, Investigation, Dylan C. Kain, Sandra Isabel, Mariana, Karel, Richard De Boissinot, Borja, N. homes, during and after before, implementation of mandates, For, COVID-19 vaccination, US among15, jurisdictions, National Healthcare, June Network, –January 2022, Sonali D. Advani, Racial disparities among, candidemic patients, A. Califórnia, Teaching Hospital, Antimicrobial, resistance in Escherichia, C. and, K. pneumoniae, urine isolates, from a national, home-based, primary care patients, dementia, clusters of COVID-19, COVID-19 Experience, A. a, tertiary-care center, Hitoshi Honda, Masataka Nakagawa, Chiyo Rie Nisida, Cost of personal, Corrigendum, safety net system, Editor-in-chief, B Editors, M. Christopher, DrPH . Sundermann, F. Donald, M. Bradley, 2007-2021, Advisory Board, M. D. Anderson, T. USAEric, Anucha, MD • Pratumthani Apisarnthanarak, Thailand Jasmine R. Marcelin, MD Mph Yehuda Carmeli, Israel • Tel Aviv, PhD T. Evans, Michael Goldmann, K. David, M. •. Bethesda, Sarah L. Krein, P. Rn, Minnesota Usa, Madaras-Kelly, B. I. U. • MPH, M. Pullman, Usa Wa, N. U. MD • Omaha   +122 more
semanticscholar   +1 more source