Results 41 to 50 of about 1,447,466 (286)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons [PDF]

, 2008
Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions.
Arko Ghosh, Arsen Hunanyan, Damien D. Pearse, James W. Fawcett, John K. Robinson, Li Lou, Lisa Schnell, Lorne M. Mendell, Martin E. Schwab, Roobeh Golshani, Victor L. Arvanian   +10 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Publisher Correction: Direct electronetting of high-performance membranes based on self-assembled 2D nanoarchitectured networks

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Shichao Zhang, Hui Liu, Ning Tang, Jianlong Ge, Jianyong Yu, Bin Ding   +5 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Displacing Lagrangian toric fibers by extended probes

, 2013
In this paper we introduce a new way of displacing Lagrangian fibers in toric symplectic manifolds, a generalization of McDuff's original method of probes. Extended probes are formed by deflecting one probe by another auxiliary probe.
Borman, Delzant, Dusa McDuff, Matthew Strom Borman, McDuff, McDuff, Miguel Abreu   +6 more
core   +3 more sources

Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]

, 1975
An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core   +2 more sources

Fused fiber couplers for fiber photometry

Cell Reports Methods, 2023
In this issue of Cell Reports Methods, Formozov et al. present an innovative fiber photometry system that uses a fused fiber coupler (FFC) instead of a dichroic mirror to split the excitation and emission light. The FFC-based photometry system is highly flexible and can be easily reconfigured to record from different biosensors.
Alex A, Legaria, Alexxai V, Kravitz
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Modelling Cotton Fiber Doffing From Saw Teeth Based On A Mathematical Model [PDF]

E3S Web of Conferences
In recent years, there have been many researches devoted to the theoretical foundations of the sawing process. However, among them, there are none devoted to the study of the process of extracting the fiber separated from the seed from the saw teeth ...
Yuldashev Khasanboy, Sharipov Khayrullo, Najmitdinov Shukhrat, Inamova Maftuna, Ruzimatov Sanjar   +4 more
doaj   +1 more source