Results 51 to 60 of about 122 (99)

Fragment‐Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
This paper by Kollár et al. reports a covalent fragment linking study against the SARS‐CoV‐2 main protease (3CLPro). Beginning with inactive fragment hits, the application of rational linker design enabled the generation of reversible covalent inhibitors exhibiting low micromolar potency. The study details some general limitations and best practices of
Levente Kollár, Levente M. Mihalovits, Dávid Bajusz, Damijan Knez, József Simon, Blake H. Balcomb, Daren Fearon, Stanislav Gobec, György M. Keserű   +8 more
wiley   +1 more source

On Bicomplex (p,q)-Fibonacci Quaternions

Mathematics
Here, we describe the bicomplex p,q-Fibonacci numbers and the bicomplex p,q-Fibonacci quaternions based on these numbers to show that bicomplex numbers are not defined the same as bicomplex quaternions.
Çağla Çelemoğlu
doaj   +1 more source

Non‐Subtractive Arterial Spin Labeling‐Based (NSASL) Renal Magnetic Resonance Angiography (MRA): Development and Clinical Feasibility Evaluation

Journal of Magnetic Resonance Imaging, Volume 63, Issue 5, Page 1435-1447, May 2026.
ABSTRACT Background Non‐contrast renal MR angiography (MRA) is valuable for patients who cannot receive contrast agents or when avoiding radiation is desired. However, the conventional inflow inversion recovery (IFIR) method is limited by incomplete background suppression, venous contamination, and motion sensitivity.
Yulin Wang, Ye Yuan, Kun Yan, Jichang Zhang, Jie Zeng, Shengyang Niu, Shiying Ke, Chendie Yao, Bin Chen, Qi Dai, Liping Guo, Jianjun Zheng, Thomas Meersmann, Chengbo Wang   +13 more
wiley   +1 more source

More Identities for Fibonacci and Lucas quaternions

Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics, 2019
Summary: In this paper, we define the associate matrix as \[ F= \left( \begin{matrix} 1+i+2j+3k & i+j+2k \\ i+j+2k & 1+j+k \end{matrix} \right). \] By the means of the matrix \(F\), we give several identities about Fibonacci and Lucas quaternions by matrix methods.
openaire   +5 more sources

Pole‐To‐Pole 3D Radial Trajectory Designs Improve Image Quality and Quantitative Parametric Mapping in the Brain and Heart

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2627-2643, May 2026.
ABSTRACT Purpose To design 3D radial spiral phyllotaxis trajectories aimed at removing phase inconsistencies, improving image quality, and enhancing parametric mapping accuracy by acquiring nearly opposing spokes starting from both hemispheres in 3D radial k‐space. Methods Two 3D radial trajectories, pole‐to‐pole and continuous spiral phyllotaxis, were
Eva S. Peper, Grzegorz Bauman, Matteo Tagliabue, Berk C. Açikgöz, Nils M. J. Plähn, Adèle L. C. Mackowiak, Yasaman Safarkhanlo, Joseph G. Woods, Davide Piccini, Li Feng, Christopher W. Roy, Oliver Bieri, Jessica A. M. Bastiaansen   +12 more
wiley   +1 more source

Mind the Gap: Linking Refactorings and Code Smells in Elixir

Journal of Software: Evolution and Process, Volume 38, Issue 5, May 2026.
ABSTRACT Elixir is a functional programming language increasingly used in the industry to develop scalable and fault‐tolerant concurrent systems more easily and with fewer computational resources. In previous studies, we cataloged 35 code smells and 82 refactorings tailored for this language, validating them with over 300 experienced developers ...
Lucas Vegi, Marco Túlio Valente
wiley   +1 more source

Learnings from Approved Antibody‐Drug Conjugates: Clinical Pharmacology Perspectives

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Over the past decade, antibody‐drug conjugates (ADCs) have emerged as promising anti‐cancer therapeutics, with twelve ADCs approved by the FDA. This review evaluates trends in these ADCs, stratified by payloads on doses studied from first‐in‐human (FIH) trials through approval and post‐marketing.
Bhargavi Thalluri, Aarti Sawant, Pavan Vajjah, Karthick Vishwanathan, Shringi Sharma   +4 more
wiley   +1 more source

Block scheduling in practice: An optimal decomposition strategy for nonidentical operating rooms

Decision Sciences, Volume 57, Issue 2, Page 95-116, April 2026.
Abstract We develop and implement a Master Surgery Schedule for a real‐life hospital, assigning operating room (OR) time to surgical specialties over a multi‐week horizon. Through action research, we identify a critical operational challenge: the issue of split blocks. Split blocks allow two specialties to share an OR on the same day—one in the morning,
Vincent J. J. van Ham, Alex Kuiper, Robert H. Lee   +2 more
wiley   +1 more source

Hausdorff dimension of double‐base expansions and binary shifts with a hole

Bulletin of the London Mathematical Society, Volume 58, Issue 4, April 2026.
Abstract For two real bases q0,q1>1$q_0, q_1 > 1$, a binary sequence i1i2⋯∈{0,1}∞$i_1 i_2 \cdots \in \lbrace 0,1\rbrace ^\infty$ is the (q0,q1)$(q_0,q_1)$‐expansion of the number πq0,q1(i1i2⋯)=∑k=1∞ikqi1⋯qik.$$\begin{equation*} \pi _{q_0,q_1}(i_1 i_2 \cdots) = \sum _{k=1}^\infty \frac{i_k}{q_{i_1} \cdots q_{i_k}}.
Jian Lu, Wolfgang Steiner, Yuru Zou
wiley   +1 more source

Quaternion algebras and the generalized Fibonacci-Lucas quaternions

, 2015
In this paper, we introduce the generalized Fibonacci-Lucas quaternions and we prove that the set of these elements is an order,in the sense of ring theory, of a quaternion algebra. Moreover, we investigate some properties of these elements.
Flaut, Cristina, Savin, Diana
openaire   +2 more sources