Results 11 to 20 of about 127,967 (338)
Fibril Breaking Accelerates α-Synuclein Fibrillization [PDF]
The Journal of Physical Chemistry B, 2015 The formation of amyloid fibrils of α-synuclein (αSyn), the key protein in Parkinson's disease, is an autocatalytic process that is seeded by mature αSyn fibrils. Based on systematic measurements of the dependence of the fibril growth rate on the concentrations of monomers and preformed fibrillar seeds, we propose a mechanism of αSyn aggregation that ...
Shvadchak, Volodymyr V. +2 more
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Frontiers in Immunology, 2023 Single-domain antibodies, also known as nanobodies, are broadly important for studying the structure and conformational states of several classes of proteins, including membrane proteins, enzymes, and amyloidogenic proteins.
Jennifer M. Zupancic +22 more
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Conformational Variability of Amyloid-β and the Morphological Diversity of Its Aggregates
Molecules, 2022 Protein folding is the most fundamental and universal example of biomolecular self-organization and is characterized as an intramolecular process. In contrast, amyloidogenic proteins can interact with one another, leading to protein aggregation.
Maho Yagi-Utsumi, Koichi Kato
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Viruses, 2022 The formation of amyloid fibers is associated with a diverse range of disease and phenotypic states. These amyloid fibers often assemble into multi-protofibril, high-order architectures in vivo and in vitro.
Wesley R. Naeimi, Tricia R. Serio
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Nature Reviews Disease Primers, 2016 Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder, and increases in prevalence with increasing age and the number of cardiovascular comorbidities. AF is characterized by a rapid and irregular heartbeat that can be asymptomatic or lead to symptoms such as palpitations, dyspnoea and dizziness.
Lip, Gregory +10 more
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Journal of Dairy Science, 2022 : Amyloid fibrils have many excellent functional properties that facilitate their applications in the food industry. There are 2 pathways for whey protein concentrate (WPC) to form amyloid fibril aggregates: spontaneous pathway and nuclear induction ...
Xiaotong Yang +7 more
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Pharmaceutics, 2022 Senile plaques composed of amyloid β (Aβ) fibrils are considered the leading cause of Alzheimer’s disease (AD). Molecules with the ability to inhibit Aβ aggregation and/or promote Aβ clearance are thus a promising approach for AD therapy.
Stéphanie Andrade +2 more
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α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear
Biomolecules, 2022 In 1957, Lionel Penrose built the first man-made self-replicating mechanical device and illustrated its function in a series of machine prototypes, prefiguring our current view of the genesis and the proliferation of amyloid fibrils.
Francesca De Giorgi +2 more
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On the tear resistance of skin. [PDF]
, 2015 Tear resistance is of vital importance in the various functions of skin, especially protection from predatorial attack. Here, we mechanistically quantify the extreme tear resistance of skin and identify the underlying structural features, which lead to ...
Gludovatz, Bernd +6 more
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Australian Journal of General Practice, 2019 Atrial fibrillation (AF) is increasingly common among Australia's ageing population and carries significant morbidity and mortality. Its detection through screening, cardiac device interrogation and/or symptoms of AF brings with it a number of significant clinical issues.The aim of this article is to outline a systematic approach to the management of ...
Kunal Pradip, Verma, Michael, Wong
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