Results 81 to 90 of about 114,998 (297)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

H-alpha features with hot onsets III. Fibrils in Lyman-alpha and with ALMA [PDF]

open access: yesA&A 598, A89 (2017), 2016
In H-alpha most of the solar surface is covered by dense canopies of long opaque fibrils, but predictions for quiet-Sun observations with ALMA have ignored this fact. Comparison with Ly-alpha suggests that the large opacity of H-alpha fibrils is caused by hot precursor events.
arxiv   +1 more source

Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress

open access: yesPathogens, 2013
Misfolding and aggregation into amyloids of the prion protein (PrP) is responsible for the development of fatal transmissible neurodegenerative diseases.
Raymond Chung   +4 more
doaj   +1 more source

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

open access: yesNature Communications, 2022
Integrated kinetic and structural investigations reveal that the ubiquitous co-chaperonin prefoldin interacts with its coiled-coil helices on the islet amyloid polypeptide fibril surface and fibril ends to inhibit fibril elongation and secondary ...
Ricarda Törner   +10 more
doaj   +1 more source

Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. [PDF]

open access: yes, 2019
Collagen remodeling occurs in many prostate pathologies; however, the underlying structural architecture in both normal and diseased prostatic tissues is largely unexplored.
Bushman, Wade A.   +5 more
core   +1 more source

Morphological properties of slender Ca II H fibrils observed by SUNRISE II

open access: yes, 2016
We use seeing-free high spatial resolution Ca II H data obtained by the SUNRISE observatory to determine properties of slender fibrils in the lower solar chromosphere.
Barthol, P.   +14 more
core   +1 more source

Entropy of water and the temperature-induced stiffening of amyloid networks [PDF]

open access: yes, 2017
In water, networks of semi-flexible fibrils of the protein $\alpha$-synuclein stiffen significantly with increasing temperature. We make plausible that this reversible stiffening is a result of hydrophobic contacts between the fibrils that become more ...
Claessens, Mireille M. A. E.   +5 more
core   +5 more sources

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

On fibrils and field lines: The nature of H$α$ fibrils in the solar chromosphere [PDF]

open access: yes, 2015
Observations of the solar chromosphere in the line-core of the \Halpha\ line show dark elongated structures called fibrils that show swaying motion. We performed a 3D radiation-MHD simulation of a network region, and computed synthetic \Halpha\ images from this simulation to investigate the relation between fibrils and the magnetic field lines in the ...
arxiv   +1 more source

Elastic moduli of collagen fibrils measured by nanoindentation test using atomic force microscope (AFM) and tensile test

open access: yesNihon Kikai Gakkai ronbunshu, 2016
Fibrils were isolated from rat tail tendons and the nanoindentation tests and tensile tests of these fibrils were performed in air (dry condition). In the nanoindentation test using atomic force microscope (AFM), the indentation depth and force of the ...
Noritaka YAMAMOTO, Shintaro YABE
doaj   +1 more source

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