Results 91 to 100 of about 750,552 (306)

Cardioprotective effects of dantrolene in doxorubicin-induced cardiomyopathy in mice

Heart Rhythm O2, 2021
Background: Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM).
Mohammed Ali Azam, MBBS, PhD, Praloy Chakraborty, MD, Mahmoud M. Bokhari, MBBS, Keith Dadson, PhD, Beibei Du, MD, PhD, Stéphane Massé, MASc, Daoyuan Si, MD, PhD, Ahmed Niri, BEng, Arjun K. Aggarwal, Patrick F.H. Lai, MSc, Sheila Riazi, MD, MSc, Filio Billia, MD, PhD, Kumaraswamy Nanthakumar, MD   +12 more
doaj  

Characteristics of Cellulose Nanofibrils from Transgenic Trees with Reduced Expression of Cellulose Synthase Interacting 1

Nanomaterials, 2022
Cellulose nanofibrils can be derived from the native load-bearing cellulose microfibrils in wood. These microfibrils are synthesized by a cellulose synthase enzyme complex that resides in the plasma membrane of developing wood cells.
Simon Jonasson, Anne Bünder, Linn Berglund, Totte Niittylä, Kristiina Oksman   +4 more
doaj   +1 more source

What drives amyloid molecules to assemble into oligomers and fibrils? [PDF]

, 2010
We develop a general theory for three states of equilibrium of amyloid peptides: the monomer, oligomer, and fibril. We assume that the oligomeric state is a disordered micelle-like collection of a few peptide chains held together loosely by hydrophobic interactions into a spherical hydrophobic core.
arxiv   +1 more source

Modeling generic aspects of ideal fibril formation [PDF]

J. Chem. Phys. 144, 035101 (2016), 2016
Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalities of fibril formation are very disparate, with various intermediate forms which can be reshuffled by minor modifications of physico-chemical conditions or amino-acid ...
arxiv   +1 more source

Atrial fibrillation and microRNAs [PDF]

Frontiers in Physiology, 2014
Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia.
Santulli, Gaetano, IACCARINO, Guido, De Luca, Nicola, Trimarco, Bruno, Condorelli, Gianluigi   +4 more
openaire   +5 more sources

Picking the Locked Door

JACC: Case Reports, 2023
The management of atrial septal defects (ASDs) has been revolutionized by the advent of percutaneous transvenous occlusion devices. This case series describes techniques required to perform a transeptal puncture safely and effectively in patients ...
Noel Fitzpatrick, MB, MSc, John Keaney, MD, Edward Keelan, MB, Kevin P. Walsh, MD, Gábor Széplaki, PhD   +4 more
doaj  

Nanoparticles With a Specific Size and Surface Charge Promote Disruption of the Secondary Structure and Amyloid-Like Fibrillation of Human Insulin Under Physiological Conditions

Frontiers in Chemistry, 2019
Nanoparticles attract much interest as fluorescent labels for diagnostic and therapeutic tools, although their applications are often hindered by size- and shape-dependent cytotoxicity.
Alyona Sukhanova, Alyona Sukhanova, Simon Poly, Svetlana Bozrova, Éléonore Lambert, Maxime Ewald, Alexander Karaulov, Michael Molinari, Igor Nabiev, Igor Nabiev   +9 more
doaj   +1 more source

Sensing Cells-Peptide Hydrogel Interaction In Situ via Scanning Ion Conductance Microscopy

Cells, 2022
Peptide-based hydrogels were shown to serve as good matrices for 3D cell culture and to be applied in the field of regenerative medicine. The study of the cell-matrix interaction is important for the understanding of cell attachment, proliferation, and ...
Tatiana N. Tikhonova, Vasilii S. Kolmogorov, Roman V. Timoshenko, Alexander N. Vaneev, Dana Cohen-Gerassi, Liubov A. Osminkina, Petr V. Gorelkin, Alexander S. Erofeev, Nikolay N. Sysoev, Lihi Adler-Abramovich, Evgeny A. Shirshin   +10 more
doaj   +1 more source

Neuro-fibrils [PDF]

The Journal of Nervous and Mental Disease, 1905
n ...
openaire   +1 more source

Nonsustained Atrial Fibrillation in Ischemic Stroke Patients and Stroke‐Free Controls From the Perspective of Stroke Pathophysiology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundShort‐lasting (
Ezgi Yetim, Mehmet Akif Topcuoglu, Ugur Canpolat, Rahsan Gocmen, Kader K. Oguz, Necla Ozer, Kudret Aytemir, Ethem Murat Arsava   +7 more
doaj   +1 more source