Results 121 to 130 of about 21,236,271 (159)

Expression of the fibrillin gene family in the development, differentiation and maintenance of mesenchyme cell types [PDF]

, 2015
Connective tissue initially arises from embryonic mesenchymal stem cells (MSC) that originate from the mesoderm during embryogenesis and are capable of differentiating into connective tissue lineages such as adipocytes, osteoblasts, chondrocytes and ...
Davis, Margaret Rose
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Decreased Gene Expression of Fibrillin-1 in Stress Urinary Incontinence

, 2010
Aims: Studies to show impairments in the pelvic floor extracellular matrix (ECM) associated with stress urinary incontinence (SUI) has earlier been performed, but the results are contradictory.
Ekman-Ordeberg, Gunvor, Soderberg, Marie Westergren, Bystrom, Birgitta, Hammarstrom, Margareta, Malmström, Anders   +4 more
core   +1 more source

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
doaj   +1 more source

Sex specific knee joint soft tissue mineralization with fibrillin-1 mutation in male tight skin mice

European Cells & Materials
Background: Articular soft tissue mineralization and ossification are clear pathological signs of osteoarthritis (OA) joints. However their molecular and cellular aetiologies remain largely unknown.
C Keenan, X Wang, T Dikmen, Y Wen, L Ramos-Mucci, E Shorter, D Abraham, G Bou-Gharios, B Poulet   +8 more
doaj   +1 more source

Fibrillin-1 gene intron 56 polymorphism in Turkish children with mitral valve prolapse

, 2010
Objective: Mitral valvar prolapse is the most common anomaly of the mitral valve apparatus throughout childhood. Fibrillin is one of the structural components of the elastin-associated microfibrils found in the mitral valve.
KULA, SERDAR, Karaer, Kadri, Olgunturk, Rana, Ozdemir, Osman, TUNAOĞLU, FATMA SEDEF, PERÇİN, FERDA EMRİYE, ERGÜN, MEHMET ALİ   +6 more
core   +1 more source

Fibrillin-integrin interactions in health and disease.

, 2008
Human fibrillin-1 is the major structural protein of extracellular matrix 10-12 nm microfibrils. It has a disulfide-rich modular organization which consists primarily of cbEGF (Ca(2+)-binding epidermal growth factor-like) domains and TB (transforming ...
Mardonf, H, Iqbal, S, Jensen, S, Mardon, H, Jovanović, J, Handford, P   +5 more
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The Fbn1 gene variant governs passive ascending aortic mechanics in the mgΔlpn mouse model of Marfan syndrome when superimposed to perlecan haploinsufficiency

Frontiers in Cardiovascular Medicine
IntroductionAscending thoracic aortic aneurysms arise from pathological tissue remodeling that leads to abnormal wall dilation and increases the risk of fatal dissection/rupture. Large variability in disease manifestations across family members who carry
Samar A. Tarraf, Rodrigo Barbosa de Souza, Ashley Herrick, Lygia V. Pereira, Chiara Bellini   +4 more
doaj   +1 more source

Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients

, 2005
Autoantibodies against short recombinant fragments of fibrillin-1 produced in bacterial expression systems have been found in tight-skin mouse, systemic sclerosis, mixed connective tissue disease, and primary pulmonary hypertension syndrome.
Sven Krengel, Dieter P Reinhardt, Brinckmann, Jürgen, Nico Hunzelmann, Ehab El-Hallous, Reinhardt, Dieter P., Krieg, Thomas, Hunzelmann, Nico, Jürgen Brinckmann, Thomas Krieg, Krengel, Sven, El-Hallous, Ehab, Sakai, Lynn Y., Lynn Y Sakai   +13 more
core   +1 more source

Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks

, 2002
Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic digestion of tissues has been utilized to release microfibrils for study.
Ono, RN, Isogai, Z, Keene, DR, Sakai, LY, Reinhardt, DP, Aspberg, Anders,, Lund University., Aspberg, Anders   +7 more
core   +1 more source

Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro.

Oxytalan fibers are distributed in the eye and periodontal ligaments (PDL). The ciliary zonule, known as Zinn's zonule, in the eye is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1 and fibrillin-2.
Oka, Kyoko, Kawagoe, Megumi, Tsuruga, Eichi, Sawa, Yoshihiko, Ishikawa, Hiroyuki   +4 more
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