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Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE

Colloids and Surfaces B: Biointerfaces, 2014
Current vascular biomaterials exhibit poor biocompatibility characterised by failure to promote endothelialisation, predisposition to neoinitmal hyperplasia and excessive thrombogenicity. Fibrillin-1, a major constituent of microfibrils is associated with elastic fibres in the arterial wall.
Hajian, Hamid   +11 more
openaire   +2 more sources

Influence of fibrillin-1 genotype on the aortic stiffness in men

Journal of Applied Physiology, 2005
Aortic stiffness is a predictor of cardiovascular mortality. The mechanical properties of the arterial wall depend on the connective tissue framework, with variation in fibrillin-1 and collagen I genes being associated with aortic stiffness and/or pulse pressure elevation.
J T, Powell   +4 more
openaire   +2 more sources

Fibrillin-1 Protein in Tight Skin Mice and Scleroderma

Clinical Reviews in Allergy & Immunology, 2000
Scleroderma (SSc) is a complex and clinically heterogenous disease of unknown origin, in which both genetic and environmental factors appear to be implicated. In addition to skin, other internal organs, including lung, heart, intestine, and kidney, can be affected.
C, Bona, S, Saito
openaire   +2 more sources

Abnormal Hepatic Expression of Fibrillin-1 in Children With Cholestasis

The American Journal of Surgical Pathology, 2002
Fibrillin-1, one of the main constituents of microfibrils, is present in normal adult liver and overexpressed in fibrotic area around cirrhotic nodules and hepatocellular carcinoma. In this work fibrillin-1 expression was studied by immunohistochemistry in liver samples from children with various cholestatic diseases corresponding to paucity of ...
Thierry, Lamireau   +6 more
openaire   +2 more sources

Role of fibrillin-1 in hypertensive and diabetic glomerular disease

American Journal of Physiology-Renal Physiology, 2006
The microfibrillar protein fibrillin-1 is a component of the mesangial matrix. Defects in fibrillin-1 predisposes individuals to vascular damage in Marfan syndrome, but the role of fibrillin-1 in kidney disease is unknown. We hypothesized that fibrillin-1 is involved in hypertensive or diabetic glomerular disease.
Andrea, Hartner   +7 more
openaire   +2 more sources

Immunohistochemical expression of Fibrillin-1 in idiopathic epiretinal membranes

Graefe's Archive for Clinical and Experimental Ophthalmology
To investigate the expression patterns of Fibrillin-1 in idiopathic epiretinal membranes (iERM) and identify Fibrillin-1-secreting cells.iERM samples were collected via standard 27-gauge vitrectomy and subsequently subjected to flat-mount immunohistochemistry with double staining for the following markers: Fibrillin-1, glial acidic fibrillary protein ...
Luu Viet Tien   +4 more
openaire   +2 more sources

Fibrillin-1

1998
Shirley Ayad   +4 more
openaire   +2 more sources

Fibrillin-1 regulates white adipose tissue development, homeostasis, and function

Matrix Biology, 2022
Muthu L Muthu   +2 more
exaly  

Fibrillin-1 assembly is dependent on fibronectin

Matrix Biology, 2008
Daliang Chen   +6 more
openaire   +1 more source

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