Results 181 to 190 of about 23,678,950 (225)

The fibrillin‐1 RGD motif posttranscriptionally regulates ERK1/2 signaling and fibroblast proliferation via miR‐1208

The FASEB Journal, 2021
Fibrillin‐1 is an extracellular matrix protein which contains one conserved RGD integrin‐binding motif. It constitutes the backbone of microfibrils in many tissues, and mutations in fibrillin‐1 cause various connective tissue disorders.
Rong-Mo Zhang, Karina A. Zeyer, N. Odenthal, Yiyun Zhang, D. Reinhardt   +4 more
semanticscholar   +1 more source

Immunohistochemical expression of Fibrillin-1 in idiopathic epiretinal membranes.

Graefe's Archive for Clinical and Experimental Ophthalmology
To investigate the expression patterns of Fibrillin-1 in idiopathic epiretinal membranes (iERM) and identify Fibrillin-1-secreting cells.iERM samples were collected via standard 27-gauge vitrectomy and subsequently subjected to flat-mount immunohistochemistry with double staining for the following markers: Fibrillin-1, glial acidic fibrillary protein ...
Luu Viet Tien, Manabu Yamamoto, M. Tagami, N. Misawa, Shigeru Honda   +4 more
semanticscholar   +3 more sources

Defective Calcium Binding to Fibrillin-1: Consequence of an N2144S Change for Fibrillin-1 Structure and Function

Journal of Molecular Biology, 1999
Fibrillin-1 is a major structural component of 10-12 nm connective tissue microfibrils and has a modular organisation that includes 43 calcium binding epidermal growth factor-like (cbEGF) domains and seven transforming growth factor beta-binding protein-like (TB) domains.
Xuemei Yuan, Penny A. Handford, Gabrielle J. Grundy, S Kettle, A. Kristina Downing, V Knott   +5 more
openaire   +3 more sources

Fibrillin-1

Definitions, 2020

semanticscholar   +2 more sources

Fibrillin-1: Organization in Microfibrils and Structural Properties

Journal of Molecular Biology, 1996
To investigate the microfibrillar organization and structural properties of fibrillin-1, we produced overlapping recombinant peptides in human cells which altogether span the fibrillin-1 molecule. The peptides were purified under non-denaturing conditions and extensive characterization indicated correct folding.
Reinhardt, Dieter P., Keene, Douglas R., Corson, Glen M., Pöschl, Ernst, Bächinger, Hans Peter, Gambee, Jay E., Sakai, Lynn Y.   +6 more
openaire   +3 more sources

Role of fibrillin-1 in hypertensive and diabetic glomerular disease [PDF]

American Journal of Physiology-Renal Physiology, 2006
The microfibrillar protein fibrillin-1 is a component of the mesangial matrix. Defects in fibrillin-1 predisposes individuals to vascular damage in Marfan syndrome, but the role of fibrillin-1 in kidney disease is unknown. We hypothesized that fibrillin-1 is involved in hypertensive or diabetic glomerular disease.
Bernd Klanke, Anke Gabriel, Markus Porst, Karl F. Hilgers, Dieter P. Reinhardt, Nada Cordasic, Andrea Hartner, Liliana Schaefer   +7 more
openaire   +2 more sources

Influence of fibrillin-1 genotype on the aortic stiffness in men [PDF]

Journal of Applied Physiology, 2005
Aortic stiffness is a predictor of cardiovascular mortality. The mechanical properties of the arterial wall depend on the connective tissue framework, with variation in fibrillin-1 and collagen I genes being associated with aortic stiffness and/or pulse pressure elevation.
Rachel Debasso, Janet T. Powell, R.J. Turner, Toste Länne, Minder Sian   +4 more
openaire   +2 more sources

Non-Enzymatic Glycation of Human Fibrillin-1

Gerontology, 2008
Non-enzymatic glycation of proteins is one of the key mechanisms in the pathogenesis of diabetic complications and may be significant in the age-related changes of tissues. We isolated and investigated the in vitro glycation of human aortic fibrillin-1. Fibrillin-1 was prepared from thoracic aortas of 9 accident victims distributed in three age groups.
Milena Atanasova, Emiliana Konova, Tatiana Betova, Stephan Baydanoff   +3 more
openaire   +3 more sources

Regulation of fibrillin-1 gene expression by Sp1

Gene, 2013
Mutations in the fibrillin-1 gene (FBN1) cause Marfan Syndrome (MFS), a hereditary disorder of connective tissue. The transcription of FBN1 has been reported to be driven by a short ultraconserved region (SUPR) in the 5' untranslated exon A of FBN1, but the nature of other factors involved in FBN1 gene regulation has not been clarified.
Christian Rödelsperger, Gao Guo, Martin Digweed, Peter N. Robinson, Peter N. Robinson   +4 more
openaire   +2 more sources

Fibrillin-1 im Bindegewebe

2017
Bindegewebe bezeichnet verschiedene Gewebetypen im Korper, die auf unterstutzende Aufgaben spezialisiert sind. Diese Gewebetypen enthalten relativ wenige Korperzellen sowie das biologische Material zwischen den Zellen, die so genannte extrazellulare Matrix.
Karina A. Zeyer, Dieter P. Reinhardt
openaire   +2 more sources