Results 61 to 70 of about 23,678,950 (225)
Fibrillin-1 microfibril deposition is dependent on fibronectin assembly [PDF]
Journal of Cell Science, 2008 Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion, but rescued by supplementation with exogenous cellular fibronectin. As integrin receptors are key determinants of fibronectin assembly, we investigated whether they also influenced microfibril ...
Kinsey, Rachel +7 more
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The evolution of extracellular fibrillins and their functional domains.
PLoS ONE, 2012 Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and non-elastic extracellular matrices, and are known to interact with several binding partners including tropoelastin and integrins.
Adam Piha-Gossack +2 more
doaj +1 more source
Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. [PDF]
PLoS Genetics, 2015 Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause ...
Gerhard Sengle +8 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2022 Background Fibrillin-1 (FBN1) is an extracellular matrix glycoprotein essential to the structural component of microfibrils and FBN1 gene polymorphisms can be associated with adolescent idiopathic scoliosis (AIS) susceptibility.
Gustavo Borges Laurindo de Azevedo +6 more
doaj +1 more source
Immunohistochemical Evaluation of Conjunctival Fibrillin-1 in Marfan Syndrome [PDF]
Archives of Ophthalmology, 2006 To evaluate status of conjunctival fibrillin-1 in patients with Marfan syndrome with ectopia lentis.Frozen sections of conjunctiva from 6 patients with Marfan syndrome with ectopia lentis and from 15 age-matched control subjects were stained with mouse antihuman fibrillin-1 antibody, using an avidin biotin immunoperoxidase technique.
Wilson Chan +9 more
openaire +3 more sources
P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE
Artery Research, 2009 Background: Fibrillin-1 is an important constituent of the vascular wall and earlier studies have indicated an effect of the fibrillin-1 2–3 genotype on blood pressure as well as aortic stiffness.
R. DeBasso +4 more
doaj +1 more source
PLoS ONE, 2012 Extracellular recombinant proteins are commonly produced using HEK293 cells as histidine-tagged proteins facilitating purification by immobilized metal affinity chromatography (IMAC).
Jasvir Kaur, Dieter P Reinhardt
doaj +1 more source
Protective Effects of Rosuvastatin on Kidney in Experimental Hypertension Rats Models
Ahi Evran Medical Journal, 2023 Purpose: Hypertension is responsible for approximately 30% of patients who reach end-stage renal disease. Statin is known to reduce the risk of developing kidney disease. In this study, the changes in caspase-3 and fibrillin1 in the kidney tissue of rats
Elif ONAT, Ahmet TÜRK, Nevin KOCAMAN
doaj +1 more source
Ocular Findings as the Most Striking Manifestation of a SMAD3 Variant
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Loeys‐Dietz syndrome (LDS) is a heritable connective tissue disorder with variable expressivity. It is a multisystemic condition mainly characterized by a propensity for arterial aneurysms and dissections, skeletal manifestations, hypertelorism, bifid uvula, craniosynostosis, and cutaneous features.
Noémie Villeneuve‐Cloutier +7 more
wiley +1 more source
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study
Veterinary Quarterly, 2021 A 4 month-old, 14.8 kg, male Newfoundland dog was presented for cardiovascular evaluation following detection of a heart murmur. Echocardiography revealed enlargement of the sinuses of Valsalva and marked, diffuse dilation of the ascending aorta ...
Etienne Côté +4 more
doaj +1 more source