Results 21 to 30 of about 22,293 (293)
Advancement of science, 2022 Extracellular matrix (ECM) remodeling is crucial in the regulation of gastric cancer (GC) progression. This work aims to reveal novel posttranslational modifications and their relevant mechanisms in GC. In 3D matrix culture and animal models, it is found
Xingyun Wang +7 more
semanticscholar +1 more source
Molecular Syndromology, 2022 Background: Asprosin is a novel fasting-induced, glucogenic, and orexigenic protein hormone that is discovered with the help of genetic studies in patients with neonatal progeroid syndrome.
M. Ovalı, I. Bozgeyik
semanticscholar +1 more source
Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? [PDF]
International Neurourology Journal, 2015 Purpose: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence.
Ayla Eser +8 more
doaj +1 more source
The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology
International Journal of Molecular Sciences, 2022 Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key physical and mechanical properties to virtually every tissue, alone and together with elastin in the elastic fibers.
Keiichi Asano +3 more
semanticscholar +1 more source
bioRxiv, 2022 Genetic mutations in fibrillin microfibrils cause a range of serious inherited diseases such as Marfan syndrome (MFS) and Weill-Marchesani syndrome (WMS). These diseases typically show major dysregulation of tissue development and growth, particularly in
Alan R. F. Godwin +9 more
semanticscholar +1 more source
Fibrillin Assembly Requires Fibronectin [PDF]
Molecular Biology of the Cell, 2008 Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and nonelastic extracellular matrices. Proper assembly mechanisms are central to the formation and function of these microfibrils, and their properties are often compromised in pathological circumstances such as in Marfan syndrome and in other fibrillinopathies.
Laetitia Sabatier +7 more
openalex +4 more sources
Science Advances, 2021 The study illustrates a crucial role of tissue microenvironment in mediating endothelial dropout and vascular rarefaction. Endothelial cell injury leading to microvascular rarefaction is a characteristic feature of chronic kidney disease (CKD).
Li Li +11 more
semanticscholar +1 more source
British Journal of Ophthalmology, 2000 The glycoprotein fibrillin is the principal component of the ciliary zonule and has an important role in the strength and elasticity of ocular connective tissues. Fibrillin polymers form the structural scaffold of extensible microfibrils1-3 which are present in ocular elastic tissues and are arranged in parallel bundles to form the zonular fibres.4 ...
Cay M. Kielty +2 more
openaire +3 more sources
Role of fibrilins in human cancer: A narrative review
Health Science Reports, 2023 Background Fibrillin is one of the extracellular matrix glycoproteins and participates in forming microfibrils found in many connective tissues. The microfibrils enable the elasticity and stretching properties of the ligaments and support connective ...
Mahsa Mahdizadehi +3 more
doaj +1 more source
Fibrillines et fibrillinopathies [PDF]
médecine/sciences, 1996 Microfibrils contain a variety of proteins, the most prominent of which are the two fibrillins. Fibrillins are large glycoproteins (320 kDa) ubiquitously distributed in connective tissues. Together with amorphous elastin, fibrillin-containing microfibrils form the elastic fibers.
Collod-Beroud, Gwenaëlle +1 more
openaire +3 more sources