Results 41 to 50 of about 1,605 (151)
Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice.
PLoS Genetics, 2015 Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause ...
Gerhard Sengle +8 more
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Fibrillines et fibrillinopathies [PDF]
médecine/sciences, 1996 Microfibrils contain a variety of proteins, the most prominent of which are the two fibrillins. Fibrillins are large glycoproteins (320 kDa) ubiquitously distributed in connective tissues. Together with amorphous elastin, fibrillin-containing microfibrils form the elastic fibers.
Collod-Beroud, Gwenaëlle +1 more
openaire +2 more sources
Innate immunity shapes the persistent transmission of plant viruses by insect vectors
New Plant Protection, EarlyView.In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley +1 more source
Fibrillins regulate the flowering time in Arabidopsis
四川大学学报. 自然科学版, 2016 In plants, multiple floral induced-pathways include vernalization signaling, gibberellin signaling, autonomous pathway and photoperiod signaling.The fbn1a/fbn8 double-mutant of Arabidopsis thaliana is acquired to study the effects of flowering time.In ...
PAN Xiang-Fei +5 more
doaj
The Supramolecular Organization of Fibrillin-Rich Microfibrils [PDF]
The Journal of Cell Biology, 2001 We propose a new model for the alignment of fibrillin molecules within fibrillin microfibrils. Automated electron tomography was used to generate three-dimensional microfibril reconstructions to 18.6-Å resolution, which revealed many new organizational details of untensioned microfibrils, including heart-shaped beads from which two arms emerge, and ...
Baldock, Clair +7 more
openaire +4 more sources
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
四川大学学报. 自然科学版, 2014 以拟南芥Columbia(Col.)生态型和Fibrillins突变体(fib8和fib1a)为研究对象,对镉胁迫条件下植株的萌发、根长生长以及植物体内H2O2和MDA含量及CAT活性的变化进行了测定.本研究发现,30μmol/L Cd2+浓度胁迫条件下,Col、fib8和fib1a的萌发未受到抑制,但根长生长都受到了抑制,fib8和fib1a的抑制程度比Col更为明显,表明突变体比野生型对镉胁迫更敏感.进一步测定镉胁迫前后Col、fib8和fib1a体内的H2O2和MDA含量及CAT活性的变化 ...
冯俊 +5 more
doaj
PLoS ONE, 2019 Classical Ehlers-Danlos syndrome (cEDS) is a dominant inherited connective tissue disorder mainly caused by mutations in the COL5A1 and COL5A2 genes encoding type V collagen (COLLV), which is a fibrillar COLL widely distributed in a variety of connective
Nicola Chiarelli +4 more
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Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source