Results 21 to 30 of about 1,767,987 (273)

PAI-1, fibrosis, and the elusive provisional fibrin matrix [PDF]

Journal of Clinical Investigation, 2000
Whether induced surgically or by hypertension, infections, extreme heat, or caustic chemicals, tissue injury invariably leads to vasodilatation, with subsequent leakage of plasma proteins into the connective tissues, rapid activation of the coagulation cascade, and deposition of fibrin.
D J, Loskutoff, J P, Quigley
openaire   +2 more sources

The degradation of gelatin/alginate/fibrin hydrogels is cell type dependent and can be modulated by targeting fibrinolysis

Frontiers in Bioengineering and Biotechnology, 2022
In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated.
Elea Boucard, Luciano Vidal, Flora Coulon, Carlos Mota, Jean-Yves Hascoët, Franck Halary   +5 more
doaj   +1 more source

Incorporation of Collagen and Hyaluronic Acid to Enhance the Bioactivity of Fibrin-Based Hydrogels for Nucleus Pulposus Regeneration

Journal of Functional Biomaterials, 2018
Hydrogels, such as fibrin, offer a promising delivery vehicle to introduce cells into the intervertebral disc (IVD) to regenerate damaged disc tissue as a potential treatment for low back pain.
Jennifer Gansau, Conor Timothy Buckley
doaj   +1 more source

Cytotoxic T lymphocyte trafficking and survival in an augmented fibrin matrix carrier. [PDF]

PLoS ONE, 2012
Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The development
Zhaoxia Zou, Erin Denny, Christine E Brown, Michael C Jensen, Gang Li, Tatsuhiro Fujii, Josh Neman, Rahul Jandial, Mike Chen   +8 more
doaj   +1 more source

Cell Transplantation and Fibrin Matrix

Journal of the American College of Cardiology, 2005
The recent study by Christman et al. ([1][1]) reports the results of an experimental study that evaluated a “novel approach to heart repair that uses an injectable biopolymer scaffold to deliver cells directly into the infarct wall.” The researchers “hypothesized that the injection of cells ...
Chekanov, Valeri, Kipshidze, Nicholas, Nikolaychik, Victor   +2 more
openaire   +1 more source

Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation

APL Bioengineering, 2019
Macrophages are versatile cells of the innate immune system that can adopt a variety of functional phenotypes depending on signals in their environment.
Jessica Y. Hsieh, Mark T. Keating, Tim D. Smith, Vijaykumar S. Meli, Elliot L. Botvinick, Wendy F. Liu   +5 more
doaj   +1 more source

Fibrin – a promising material for vascular tissue engineering

Вестник трансплантологии и искусственных органов, 2020
This review looks at the use of fibrin in vascular tissue engineering (VTE). Autologous fibrin is one of the most affordable biopolymers because it can be obtained from peripheral blood by simple techniques.
V. G. Matveeva, M. U. Khanova, L. V. Antonova, L. S. Barbarash   +3 more
doaj   +1 more source

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants.

PLoS Computational Biology, 2018
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low
Sonja E M Boas, Joao Carvalho, Joao Carvalho, Marloes van den Broek, Ester M Weijers, Marie-José Goumans, Pieter Koolwijk, Roeland M H Merks   +7 more
doaj   +1 more source

Compression-induced structural and mechanical changes of fibrin-collagen composites [PDF]

, 2017
Fibrin and collagen as well as their combinations play an important biological role in tissue regeneration and are widely employed in surgery as fleeces or sealants and in bioengineering as tissue scaffolds.
Chen, J, Litvinov, RI, Chen, J., Kim, O. V., Weisel, J.W., Alber, MS, Chen, DZ, Chen, D. Z., Alber, M. S., Weisel, JW, Kim, OV, Litvinov, R. I.   +11 more
core   +1 more source

Coupling of Fibrin Reorganization and Fibronectin Patterning by Corneal Fibroblasts in Response to PDGF BB and TGFβ1

Bioengineering, 2020
We previously reported that corneal fibroblasts within 3D fibrin matrices secrete, bind, and organize fibronectin into tracks that facilitate cell spreading and migration.
Miguel Miron-Mendoza, Dalia Vazquez, Nerea García-Rámila, Hikaru R. Ikebe, W. Matthew Petroll   +4 more
doaj   +1 more source