Results 31 to 40 of about 1,767,987 (273)

A systematic literature review of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors [PDF]

, 2021
8 p.Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or without growth factors. Methods: A systematic review of the literature was performed to evaluate the use of fibrin matrices with or ...
Cantini Ardila, Jorge Ernesto, Gómez-Ortega, Viviana, García Botero, Alejandra, Devoz Borja, Luis David   +3 more
core   +1 more source

Synergistic Effect of Keratinocyte Transplantation and Epidermal Growth Factor Delivery on Epidermal Regeneration

Cell Transplantation, 2005
Both keratinocyte transplantation and epidermal growth factor (EGF) delivery stimulate epidermal regeneration. In this study, we hypothesized that the combined therapy of keratinocyte transplantation and EGF delivery accelerates epidermal regeneration ...
So-Jung Gwak, Sang-Soo Kim, Kyungeun Sung, Joungho Han, Cha Yong Choi, Byung-Soo Kim   +5 more
doaj   +1 more source

Covalent Cross-linking of Fibronectin to Fibrin Is Required for Maximal Cell Adhesion to a Fibronectin-Fibrin Matrix [PDF]

Journal of Biological Chemistry, 1997
In a blood clot, fibrin and plasma fibronectin (pFN) are covalently cross-linked by activated factor XIII (factor XIIIa) to form pFN-fibrin multimers. To determine the functional significance of covalent pFN-fibrin interactions, we have developed an in vitro model which allows the incorporation of recombinant FN (recFN) molecules into a covalently ...
S A, Corbett, L, Lee, C L, Wilson, J E, Schwarzbauer   +3 more
openaire   +2 more sources

Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin [PDF]

Scientific Reports, 2020
Abstract The roles of protein conformational dynamics and allostery in function are well-known. However, the roles that interdomain dynamics have in function are not entirely understood. We used matrix metalloprotease-1 (MMP1) as a model system to study the relationship between interdomain dynamics and activity because MMP1 has ...
Kumar, Lokender, Planas-Iglesias, Joan, Harms, Chase, Kamboj, Sumaer, Wright, Derek, Klein-Seetharaman, Judith, Sarkar, Susanta K.   +6 more
openaire   +2 more sources

Three-Dimensional Culture of Human Nucleus Pulposus Cells in Fibrin Clot: Comparisons on Cellular Proliferation and Matrix Synthesis with Cells in Alginate

, 2011
Regeneration of nucleus pulposus (NP) tissue may stop or reverse early intervertebral disk (IVD) degeneration. Cellular proliferation and matrix synthesis can be promoted by incorporation of cells and bioscaffolds.
YANG, SHU-HUA;WU, CHANG-CHIN;SHIH, TIFFANY TING- FANG;CHEN, PO-QUANG;LIN, FENG-HUEI;LIN, FENG- HUEI, 楊曙華;吳長晉;施庭芳;陳博光;林峰輝   +1 more
core   +1 more source

3D Fibrin Gels Direct Extracellular Matrix Production in Intervertebral Disc Cells under Hypoxic Conditions

Global Spine Journal, 2014
Introduction Fibrin gels are considered to be a promising biomaterial for tissue engineering because of its role as a “physiological scaffold” in tissue regeneration.
X. Tang, A. Ouyang, E. Liebenberg, J. Lotz   +3 more
doaj   +1 more source

Advantages of Fibrin Polymerization Method without the Use of Exogenous Thrombin for Vascular Tissue Engineering Applications

Biomedicines, 2022
Fibrin is widely used in vascular tissue engineering. Typically, fibrin polymerization is initiated by adding exogenous thrombin. In this study, we proposed a protocol for the preparation of completely autologous fibrin without the use of endogenous ...
Vera G. Matveeva, Evgenia A. Senokosova, Viktoriia V. Sevostianova, Mariam Yu. Khanova, Tatiana V. Glushkova, Tatiana N. Akentieva, Larisa V. Antonova, Leonid S. Barbarash   +7 more
doaj   +1 more source

Polyphosphate nanoparticles enhance the fibrin stabilization by histones more efficiently than linear polyphosphates

PLoS ONE, 2022
Introduction Beyond the three-dimensional fibrin network, the mechanical and lytic stability of thrombi is supported by the matrix of neutrophil extracellular traps (NETs) composed of polyanionic DNA meshwork with attached proteins including polycationic
Miklós Lovas, Anna Tanka-Salamon, László Beinrohr, István Voszka, László Szabó, Kinga Molnár, Krasimir Kolev   +6 more
doaj   +2 more sources

Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials
Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes to repair or even enhance the functions of diseased tissues and organs.
Songjie Li, Xin Dan, Han Chen, Tong Li, Bo Liu, Yikun Ju, Yang Li, Lanjie Lei, Xing Fan   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source