Acta Obstetricia et Gynecologica Scandinavica, EarlyView.In this retrospective cohort study, the vacuum‐assisted hemorrhage‐control device for refractory postpartum hemorrhage, implemented within an E‐MOTIVE and ROTEM‐guided protocol, was associated with reduced transfusion requirements, decreased device indwelling time, fewer high‐dependency admissions, and a shorter duration of hospital stay compared to ...
Kelvin Z. X. Lee +13 more
wiley +1 more source
Biomaterial-mediated blood clot formation: a key to unlocking osteogenic synergy for bone regeneration. [PDF]
Bone ResZhang D +5 more
europepmc +1 more source
Initial V‐A ECMO Flow‐Index and Its Association With Inflammation, Organ Failure, and Outcomes
Artificial Organs, EarlyView.Higher initial V‐A ECMO flow‐index was associated with greater shock severity and independently associated with multi‐organ failure. Early hemolysis may partly contribute to this association, particularly in eCPR patients, whereas no significant indirect effect through IL‐6 was observed.
Kostiantyn Kozakov +9 more
wiley +1 more source
Comparative Biochemical and Functional Characterization of a Novel Human Fibrinogen Concentrate (BT524) and Established Plasma-Derived Fibrinogen Concentrates. [PDF]
Drug Res (Stuttg)Bergmann M, Rübsamen D, Kistner S.
europepmc +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
Peripheral Blood Neutrophil-to-Lymphocyte Ratio Combined With Fibrinogen-to-Albumin Ratio Assists in Identifying Systemic Lupus Erythematosus Activity and Lupus Nephritis. [PDF]
APMISWang S, Xue Y, Zhou L.
europepmc +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Development and validation of a predictive nomogram for myopenia in patients with decompensated cirrhosis. [PDF]
Front Med (Lausanne)Yuan X, Yang X, Du X, Zhou Y.
europepmc +1 more source
Molecular-gated MRI <i>via</i> α<sub>IIb</sub>β<sub>3</sub>: ligand-triggered relaxation switching for efficient imaging of activated platelet-driven thrombosis. [PDF]
Mater Today BioYu X +8 more
europepmc +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source