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European Heart Journal, 1995
As evidence accumulates to implicate fibrinogen as a risk factor for cardiovascular disease (CVD) it becomes important to characterize the levels and correlates of fibrinogen in diverse populations. Knowledge of the correlates of fibrinogen may help researchers to disentangle the independent contribution of elevated fibrinogen concentrations to CVD ...
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As evidence accumulates to implicate fibrinogen as a risk factor for cardiovascular disease (CVD) it becomes important to characterize the levels and correlates of fibrinogen in diverse populations. Knowledge of the correlates of fibrinogen may help researchers to disentangle the independent contribution of elevated fibrinogen concentrations to CVD ...
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Fibrinogen as a Hemostatic Agent
Seminars in Thrombosis and Hemostasis, 2012Coagulation factor I (fibrinogen) plays an essential role in the hemostatic system by bridging activated platelets and being the key substrate for thrombin in establishing a consolidating fibrin network. Fibrinogen is synthesized in the liver and the plasma concentration is 1 to 5-4.0 g/L.
Sørensen, Benny +5 more
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Annals of the New York Academy of Sciences, 2001
Abstract:The progression of a tumor from benign and localized to invasive and metastatic growth is the major cause of poor clinical outcome in cancer patients. Much like in a healing wound, the deposition of fibrin(ogen), along with other adhesive glycoproteins, into the extracellular matrix (ECM) serves as a scaffold to support binding of growth ...
P J, Simpson-Haidaris, B, Rybarczyk
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Abstract:The progression of a tumor from benign and localized to invasive and metastatic growth is the major cause of poor clinical outcome in cancer patients. Much like in a healing wound, the deposition of fibrin(ogen), along with other adhesive glycoproteins, into the extracellular matrix (ECM) serves as a scaffold to support binding of growth ...
P J, Simpson-Haidaris, B, Rybarczyk
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ON THE IDENTITY OF PLATELET FIBRINOGEN WITH PLASMA FIBRINOGEN
Thrombosis and Haemostasis, 1987It is a well established fact that fibrinogen occurs not only in blood plasma but also in the α-granules of the platelets. Recently, it has been shown that fibrinogen is synthesised in the megakaryocytes as well as in the liver. Plasma fibrinogen is derived from the liver, but platelet fibrinogen either exclusively or partially from the megakaryocytes.
H Kaudewitz, A Henschen, R E Zimmermann
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Annual Review of Biochemistry, 1975
Fibrinogen is a soluble plasma protein that is converted to polymeric fibrin in response to damage to the vascular system. The clotting process is initiated when platelets aggregate at the wound site. Their disruption releases biologically active amines and a proteolytic cascade follows which culminates in the conversion of fibrinogen to fibrin.
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Fibrinogen is a soluble plasma protein that is converted to polymeric fibrin in response to damage to the vascular system. The clotting process is initiated when platelets aggregate at the wound site. Their disruption releases biologically active amines and a proteolytic cascade follows which culminates in the conversion of fibrinogen to fibrin.
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Fibrinogen Troyes - Fibrinogen Metz
Thrombosis and Haemostasis, 1972SummaryTwo new cases of congenital dysfibrinogenemia have been discovered. In the first case, “Fibrinogen TROYES”, the abnormality is characterized by a prolonged thrombin clotting time, the defect being due to abnormal aggregation of fibrin monomers. There is no tendency towards excessive bleeding.
J, Soria +4 more
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Radioimmunoassay of fibrinopeptide A — Immunoreactivity of fibrinogen and fibrinogen fragments
Thrombosis Research, 1980Abstract Anti-fibrinopeptide A antisera with different immunochemical specificities for human fibrinopeptide A (FPA), when it is part of fibrinogen or fibrinogen fragments, were used in the radioimmunoassay of FPA to demonstrate different susceptibility of native and purified molecules to degradation.
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Fibrinogen and fibrinogen-related peptides in cancer
1984At a previous International Symposium on Plasma Protein Metabolism1 we presented evidence that patients with advanced carcinomas of the lung, pancreas and liver metabolise fibrinogen abnormally. Figure 13.1 shows the overall schema for fibrinogen synthesis, distribution and metabolism which we used to obtain that evidence2. In health, fibrinogen mainly,
J. J. Franks +3 more
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Biochemistry and Measurement of Fibrinogen
European Heart Journal, 1995Fibrinogen is a large heterogeneous family of closely related molecules consisting of three pairs of non-identical polypeptide chains: two A alpha-, two B beta- and two gamma-chains, held together by disulphide bridges. The heterogeneity of fibrinogen is due to heterogeneities in all three chains.
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Fibrinogen Concentrates for Acquired Fibrinogen Deficiencies?
Seminars in Thrombosis and Hemostasis, 2016Surgical bleeding has been decreasing steadily for the last 20 years, but there are still some hemorrhagic procedures occurring in scheduled surgical settings and emergency procedures. The interest in potent hemostatic agents has recently focused on fibrinogen concentrates.
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