Results 121 to 130 of about 1,131,844 (424)
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
The effects of fibroblasts on wave dynamics in a mathematical model for human ventricular tissue [PDF]
arXiv, 2016 We present systematic numerical studies of electrical-wave propagation in two-dimensional (2D) and three-dimensional (3D) mathematical models, for human, ventricular tissue with myocyte cells that are attached (a) regularly and (b) randomly to distributed fibroblasts. In both these cases we show that there is a parameter regime in which single rotating
arxiv
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Ex vivo engineering of blood and lymphatic microvascular networks
Vascular Biology, 2019 Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging.
Jaana Schneider +2 more
doaj +1 more source
Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling
Frontiers in Physiology, 2019 After injury to periodontal tissues, a sequentially phased healing response is initiated that enables wound closure and partial restoration of tissue structure and function. Wound closure in periodontal tissues involves the tightly regulated coordination
Patricio C. Smith +3 more
doaj +1 more source
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing
Bioengineering & Translational Medicine, 2022 Effective skin wound healing is a complex process involving anti‐inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage‐mediated anti‐inflammation and fibroblast‐assisted matrix reconstruction for ...
Dongqing Wang +9 more
doaj +1 more source
A master relation defines the nonlinear viscoelasticity of single fibroblasts [PDF]
, 2006 Cell mechanical functions like locomotion, contraction and division are controlled by the cytoskeleton, a dynamic biopolymer network whose mechanical properties remain poorly understood. We perform single-cell uniaxial stretching experiments on 3T3 fibroblasts.
arxiv +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1471-1492, May 2025.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]
, 2015 Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa +2 more
core +2 more sources
Journal of Nuclear Medicine, 2019 Heart failure remains a major source of late morbidity and mortality after myocardial infarction (MI). The temporospatial presence of activated fibroblasts in the injured myocardium predicts the quality of cardiac remodeling after MI.
Zohreh Varasteh +13 more
semanticscholar +1 more source