Results 151 to 160 of about 1,131,844 (424)

Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts

Frontiers in Cell and Developmental Biology, 2014
Recently, the numbers of patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have increased worldwide. NAFLD and NASH are known as risk factors for liver cirrhosis and hepatocellular carcinoma.
Shizuka eMiura, Atsushi eSuzuki
doaj   +1 more source

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance The central concept in this study is that a major cytoskeletal component, vimentin, acts as a signal integrator during wound healing, operating in both signal-triggering and signal-receiving cells. This is a previously unreported concept for
Fang Cheng, Yue-ming Shen, P. Mohanasundaram, M. Lindström, J. Ivaska, T. Ny, J. Eriksson   +6 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation

Biomolecules, 2015
Chronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue damage involves a carefully choreographed series
Alvaro Valin, José L. Pablos
doaj   +1 more source

Piezoelectric Drop-on-Demand Inkjet Printing of Rat Fibroblast Cells: Survivability Study and Pattern Printing [PDF]

arXiv, 2013
A novel piezoelectric, drop-on-demand (DOD) inkjet system has been developed and used to print L929 rat fibroblast cells. We investigate the survivability of the cells subjected to the large stresses during the printing process. These stresses are varied by changing the diameter of the orifice (36 to 119 microns) through which the cells are dispensed ...
arxiv  

Effects of etelcalcetide on fibroblast growth factor 23 in patients with secondary hyperparathyroidism receiving hemodialysis [PDF]

, 2019
Background: Etelcalcetide is an intravenous calcimimetic approved for treatment of secondary hyperparathyroidism (sHPT) in patients receiving hemodialysis. Besides lowering parathyroid hormone (PTH), etelcalcetide also significantly reduces fibroblast
Block, Geoffrey A., Chertow, Glenn M., Cooper, Kerry, Fouqueray, Bruno, Moe, Sharon M., Oberbauer, Rainer, Sun, Yan, Tomlin, Holly, Vervloet, Marc, Wolf, Myles   +9 more
core   +1 more source

Fibroblast biology. Signals targeting the synovial fibroblast in arthritis.

Arthritis research, 2000
Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid soluble, small molecular weight mediators (eg nitric oxide [NO], prostaglandins, carbon monoxide); extracellular matrix (ECM)-cell interactions; and direct ...
Xu Jw, Yrjö T. Konttinen, Mika Hukkanen, Ismo Virtanen, Tian-Fang Li, Jian Ma   +5 more
openaire   +3 more sources

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors

Frontiers in Molecular Biosciences, 2019
Increasing evidence indicates that the heterogeneous tumor stroma supports therapy resistance at multiple levels. Fibroblasts, particularly cancer-associated fibroblasts (CAFs) are critical components of the tumor stroma.
Alizée Steer, Nils Cordes, Nils Cordes, Nils Cordes, Nils Cordes, Nils Cordes, Verena Jendrossek, Diana Klein   +7 more
doaj   +1 more source

SPI1/PU.1 controls fibroblast polarization and tissue fibrosis

Nature, 2019
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
T. Wohlfahrt, S. Rauber, S. Uebe, M. Luber, A. Soare, A. Ekici, S. Weber, A. Matei, Chih-Wei Chen, C. Maier, E. Karouzakis, H. Kiener, E. Pachera, C. Dees, C. Beyer, C. Daniel, K. Gelse, A. Kremer, E. Naschberger, M. Stürzl, F. Butter, M. Sticherling, S. Finotto, A. Kreuter, M. Kaplan, A. Jüngel, S. Gay, S. Nutt, D. Boykin, G. Poon, O. Distler, G. Schett, J. Distler, A. Ramming   +33 more
semanticscholar   +1 more source