Results 161 to 170 of about 1,131,844 (424)

Evidence of Fibroblast Heterogeneity and the Role of Fibroblast Subpopulations in Fibrosis

Clinical Immunology and Immunopathology, 1994
This review article highlights the evidence supporting the concept that, like lymphocytes, fibroblasts also consist of subpopulations with unique phenotypes and functions. A new view of the fibroblast is that they are dynamic and consist of subsets which produce cytokines and interact with the immune system.
Gregory D. Sempowski, R J Looney, Richard P. Phipps, Maria R. Silvera, Kristin M. Fries, Timothy M. Blieden, Richard A. Willis   +6 more
openaire   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Modelling Protein Synthesis as A Biomarker in Fragile X Syndrome Patient-Derived Cells

Brain Sciences, 2019
The most conserved molecular phenotype of Fragile X Syndrome (FXS) is aberrant protein synthesis. This has been validated in a variety of experimental model systems from zebrafish to rats, patient-derived lymphoblasts and fibroblasts.
Rakhi Pal, Aditi Bhattacharya
doaj   +1 more source

Collective properties of cellular identity: a computational approach [PDF]

arXiv, 2013
Cell type (e.g. pluripotent cell, fibroblast) is the end result of many complex processes that unfold due to evolutionary, developmental, and transformational stimuli. A cell's phenotype and the discrete, a priori states that define various cell subtypes (e.g.
arxiv  

Development and AFM study of porous scaffolds for wound healing applications [PDF]

, 2004
An engineering approach to the development of biomaterials for promotion of wound healing emphasises the importance of a well-controlled architecture and concentrates on optimisation of morphology and surface chemistry to stimulate guidance of the ...
Bowen, W.R., Doneva, T.A., Stephens, P., Thomas, D.W., Yin, H.B.   +4 more
core   +2 more sources

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Journal of Clinical Investigation, 2014
In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure.
C. Bang, S. Batkai, S. Dangwal, Shashi K. Gupta, A. Foinquinos, A. Holzmann, A. Just, J. Remke, K. Zimmer, A. Zeug, E. Ponimaskin, A. Schmiedl, X. Yin, M. Mayr, Rashi Halder, A. Fischer, S. Engelhardt, Yuanyuan Wei, A. Schober, J. Fiedler, T. Thum   +20 more
semanticscholar   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, Volume 19, Issue 5, Page 1295-1298, May 2025.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

EphA2 is a biomarker of hMSCs derived from human placenta and umbilical cord

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: The heterogeneous nature of mesenchymal stem cells (MSCs) and the absence of known MSC-specific biomarkers make it challenging to define MSC phenotypes and characteristics.
Shih-Pei Shen, Wei-Ting Liu, Yun Lin, Yuan-Tsung Li, Chih-Hao Chang, Fung-Wei Chang, Le-Ming Wang, Sen-Wen Teng, Yogi Hsuan   +8 more
doaj   +1 more source

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]

, 2007
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L, Firestein, Gary S, Hammaker, Deepa R, Inoue, Tomoyuki   +3 more
core   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source