Results 181 to 190 of about 1,131,844 (424)

An Algorithm for Cellular Reprogramming

open access: yes, 2017
The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away.
Bloch, Anthony   +7 more
core   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis [PDF]

open access: yesEuropean Respiratory Review, 2012
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of
A. Günther   +5 more
doaj  

Fibroblast-to-myofibroblast transition in bronchial asthma

open access: yesCellular and Molecular Life Sciences, 2018
Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an ...
M. Michalik   +7 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

Loss of Cell-Substrate Adhesion Leads to Periodic Shape Oscillations in Fibroblasts [PDF]

open access: yesarXiv, 2006
We report the phenomenon of periodic shape oscillations occurring in 3T3 fibroblasts merely as a consequence of a loss of cell-substrate adhesion. The oscillatory behavior can last many hours at a constant frequency, and can be switched off and on using chemical agents.
arxiv  

A novel model for one-dimensional morphoelasticity. Part II - Application to the contraction of fibroblast-populated collagen lattices [PDF]

open access: yes, 2011
Fibroblast-populated collagen lattices are commonly used in experiments to study the interplay between fibroblasts and their pliable environment. Depending on the method by which\ud they are set, these lattices can contract significantly, in some cases ...
Hall, C. L.   +3 more
core  

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