Results 211 to 220 of about 1,131,844 (424)
Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero +15 more
wiley +1 more source
Actuation of Cell Sheets in 3D [PDF]
arXivThe alignment of fibers and cells in living tissues affect their mechanical properties and functionality. In this context, one can draw an analogy between living tissues and nematic liquid crystal elastomers. We explore this analogy by growing fibroblasts to high density on 2D patterned substrates and observing the contraction of cell sheets upon ...
arxiv
Tumor-stroma interactions influence the response to PI3K targeted agents in preclinical models of colorectal cancer (CRC) [PDF]
, 2019 Introduction: One of the main obstacle to the successful development of therapeutic strategies remains the identification of biomarker underlying drug resistance. Recently, investigators have become more aware the role of the tumor microenvironment (TME)
Bazzichetto, Chiara
core
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
Rapid prediction of organisation in engineered corneal, glial and fibroblast tissues using machine learning and biophysical models [PDF]
arXivWe present a machine learning approach for predicting the organisation of corneal, glial and fibroblast cells in 3D cultures used for tissue engineering. Our machine-learning-based method uses a powerful generative adversarial network architecture called pix2pix, which we train using results from biophysical contractile network dipole orientation ...
arxiv
Synthesis of collagen and hyaluronic acid by fibroblast hybrids. [PDF]
, 1966 H Green +3 more
openalex +1 more source
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.
Cancer Cell, 2018 Ana Costa +18 more
semanticscholar +1 more source
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source