Results 41 to 50 of about 78,520,259 (248)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]

, 1995
PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
core   +2 more sources

Role of fibroblast growth factor 8 in growth and progression of hormonal cancer

, 2007
Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas.
Härkönen, Pirkko,, Mattila, Mirjami A., Lund University.   +2 more
core   +2 more sources

Obese asthma phenotypes display distinct plasma biomarker profiles

Clinical and Translational Allergy, 2023
Background Obese asthma is a complex phenotype and further characterization of the pathophysiology is needed. This study aimed to explore inflammation‐related plasma biomarkers in lean and overweight/obese asthmatics.
Sophia Björkander, Susanna Klevebro, Natalia Hernandez‐Pacheco, Maura Kere, Sandra Ekström, Maria Sparreman Mikus, Marianne vanHage, Anna James, Inger Kull, Anna Bergström, Jenny Mjösberg, Christopher Andrew Tibbitt, Erik Melén   +12 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer

Frontiers in Cell and Developmental Biology, 2020
Fibroblast growth factor 10 (Fgf10) is a secreted ligand acting via the Fibroblast growth factor receptor 2b (Fgfr2b). Fgf10/Fgfr2b signaling plays important roles both in the epithelium and in the mesenchyme during mammary gland development. Evidence in
Stefano Rivetti, Stefano Rivetti, Chaolei Chen, Chengshui Chen, Saverio Bellusci, Saverio Bellusci   +5 more
doaj   +1 more source

Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. [PDF]

PLoS ONE, 2012
Fibroblast growth factor 10 (Fgf10) is a key regulator of diverse organogenetic programs during mouse development, particularly branching morphogenesis. Fgf10-null mice suffer from lung and limb agenesis as well as cecal and colonic atresia and are thus ...
Elie El Agha, Denise Al Alam, Gianni Carraro, Breanne MacKenzie, Kerstin Goth, Stijn P De Langhe, Robert Voswinckel, Mohammad K Hajihosseini, Virender K Rehan, Saverio Bellusci   +9 more
doaj   +1 more source

Mathematical analysis of a model for the growth of the bovine corpus luteum [PDF]

, 2013
The corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy.
Mann, George, Jeffrey, Mike R., Owen, Marcus, Prokopiou, Sotiris, Prokopiou, Sotiris A., Owen, Markus R., Byrne, Helen, Jeffrey, Mike R, Mann, George E., Byrne, Helen M., Robinson, Robert S., Robinson, RL   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source