Regulation of FGF10 Signaling in Development and Disease [PDF]
Frontiers in Genetics, 2018 Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults.
Joanne Watson, Chiara Francavilla
exaly +9 more sources
Myocardial protection by heparin-based coacervate of FGF10
Bioactive Materials, 2021 Heart disease is still the leading killer all around the world, and its incidence is expected to increase over the next decade. Previous reports have already shown the role of fibroblast growth factor10 (FGF10) in alleviating heart diseases.
Zhouguang Wang +7 more
doaj +4 more sources
FGF10 ameliorates epileptic seizures and related cognitive dysfunction via the FGFR2/CALB1 signaling pathway [PDF]
Journal of Translational MedicineBackground Temporal lobe epilepsy (TLE) is frequently associated with cognitive impairments, such as memory deficits, attention disorders, and executive dysfunction.
Linqian Zhao +7 more
doaj +3 more sources
Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer [PDF]
Frontiers in Cell and Developmental Biology, 2020 Fibroblast growth factor 10 (Fgf10) is a secreted ligand acting via the Fibroblast growth factor receptor 2b (Fgfr2b). Fgf10/Fgfr2b signaling plays important roles both in the epithelium and in the mesenchyme during mammary gland development. Evidence in
Chengshui Chen +2 more
exaly +7 more sources
Phenotypic spectrum of FGF10-related disorders: a systematic review [PDF]
PeerJ, 2022 FGF10, as an FGFR2b-specific ligand, plays a crucial role during cell proliferation, multi-organ development, and tissue injury repair. The developmental importance of FGF10 has been emphasized by the identification of FGF10 abnormalities in human ...
Katarzyna Bzdega, Justyna A. Karolak
doaj +4 more sources
Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling [PDF]
Clinical and Translational MedicineBackground Metabolic dysfunction–associated steatotic liver disease (MASLD) and advanced fibrotic stages are significant contributors to cirrhosis and liver‐related mortality, yet no therapies directly target fibrosis in the later stages of the disease ...
Xuanxin Yang +20 more
doaj +2 more sources
Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune niches [PDF]
Clinical and Translational MedicineBackground Acute respiratory distress syndrome (ARDS) is a life‐threatening condition characterized by high mortality with no specific treatments. Fibroblast growth factor 10 (FGF10) is recognized for its tissue repair and anti‐inflammatory roles in ...
Tianchang Wei +10 more
doaj +2 more sources
Multiple Cranial Organ Defects After Conditionally Knocking Out Fgf10 in the Neural Crest
Frontiers in Physiology, 2016 Fgf10 is necessary for the development of a number of organs that fail to develop or are reduced in size in the null mutant. Here we have knocked out Fgf10 specifically in the neural crest driven by Wnt1cre.
Abigail S. Tucker +2 more
exaly +3 more sources
Redox Biology, 2021 Hepatic ischemia-reperfusion injury (IRI) is a major complication of liver surgery and transplantation. IRI leads to hepatic parenchymal cell death, resulting in liver failure, and lacks effective therapeutic approaches.
Santie Li +18 more
doaj +1 more source
Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. [PDF]
PLoS ONE, 2012 Fibroblast growth factor 10 (Fgf10) is a key regulator of diverse organogenetic programs during mouse development, particularly branching morphogenesis. Fgf10-null mice suffer from lung and limb agenesis as well as cecal and colonic atresia and are thus ...
Elie El Agha +9 more
doaj +1 more source