The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice [PDF]
Redox Biology, 2021 Hepatic ischemia-reperfusion injury (IRI) is a major complication of liver surgery and transplantation. IRI leads to hepatic parenchymal cell death, resulting in liver failure, and lacks effective therapeutic approaches.
Santie Li +18 more
doaj +2 more sources
The Role of Fibroblast Growth Factor 10 Signaling in Duodenal Atresia [PDF]
Frontiers in Pharmacology, 2020 IntroductionDuodenal atresia (DA) is a congenital bowel obstruction requiring major surgery in the first week of life. Three morphological phenotypes are described, reflecting increasing degrees of obstruction and discontinuity of the duodenum. The cause
Matthew L. M. Jones +15 more
doaj +2 more sources
Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis [PDF]
Respiratory Research, 2022 Highlights It is the first time to prove the confirm the endothelial glycocalyx impairment in COPD. FGF10 attenuates the development of emphysema and the shedding of glycocalyx induced by CSE in vivo.
Tian Jiang +8 more
doaj +2 more sources
Association of fibroblast growth factor 10 with the fibrotic and inflammatory pathogenesis of Graves' orbitopathy. [PDF]
PLoS ONE, 2021 PurposeThe role of fibroblast growth factor (FGF) in orbital fibroblasts (OFs) is rarely known. In this study, we investigated the effect of FGF10 on fibrosis and the inflammation mechanism of Graves' orbitopathy (GO).MethodsOrbital tissue from GO (n ...
Sun Young Jang +4 more
doaj +2 more sources
Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1) [PDF]
Biology, 2022 For heart regeneration purposes, embryonic stem cell (ES)-based strategies have been developed to induce the proliferation of cardiac progenitor cells towards cardiomyocytes.
Farhad Khosravi +3 more
doaj +2 more sources
Fibroblast Growth Factor 10 and Vertebrate Limb Development [PDF]
Frontiers in Genetics, 2019 Early limb development requires fibroblast growth factor (Fgf)-mediated coordination between growth and patterning to ensure the proper formation of a functional organ.
Libo Jin +7 more
doaj +2 more sources
Emerging Roles of Fibroblast Growth Factor 10 in Cancer [PDF]
Frontiers in Genetics, 2018 Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10
Natasha S. Clayton, Richard P. Grose
doaj +2 more sources
Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling [PDF]
Clinical and Translational MedicineBackground Metabolic dysfunction–associated steatotic liver disease (MASLD) and advanced fibrotic stages are significant contributors to cirrhosis and liver‐related mortality, yet no therapies directly target fibrosis in the later stages of the disease ...
Xuanxin Yang +20 more
doaj +2 more sources
Fibroblast Growth Factor 10 in Pancreas Development and Pancreatic Cancer [PDF]
Frontiers in Genetics, 2018 The tenacious prevalence of human pancreatic diseases such as diabetes mellitus and adenocarcinoma has prompted huge research interest in better understanding of pancreatic organogenesis.
Rodrick Ndlovu +7 more
doaj +2 more sources
Fibroblast Growth Factor 10 Attenuates Renal Damage by Regulating Endoplasmic Reticulum Stress After Ischemia–Reperfusion Injury [PDF]
Frontiers in Pharmacology, 2020 Renal ischemia–reperfusion (I/R) injury is a predominant cause of acute kidney injury (AKI), the pathologic mechanism of which is highly complex involving reactive oxygen species (ROS) accumulation, inflammatory response, autophagy, apoptosis as well as ...
Xiaohua Tan +8 more
doaj +2 more sources