Results 31 to 40 of about 11,138 (199)

Requirements for FGF3 and FGF10 during inner ear formation [PDF]

Development, 2003
Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and organogenesis in vertebrates. FGF3 is expressed in the developing hindbrain and has been shown to be involved in inner ear development of different vertebrate species, including zebrafish, Xenopus, chick and mouse.
Alvarez, Yolanda, Alonso, Maria Teresa, Vendrell, Victor, Zelarayan, Laura Cecilia, Chamero, Pablo, Theil, Thomas, Bösl, Michael R., Kato, Shigeaki, Maconochie, Mark, Riethmacher, Dieter, Schimmang, Thomas   +10 more
openaire   +4 more sources

FGF10 signaling controls stomach morphogenesis

Developmental Biology, 2007
Maintenance of progenitor cell properties in development is required for proper organogenesis of most organs, including those derived from the endoderm. FGF10 has been shown to play a role in both lung and pancreatic development. Here we find that FGF10 signaling controls stomach progenitor maintenance, morphogenesis and cellular differentiation ...
Nyeng, Pia, Norgaard, Gitte Anker, Kobberup, Sune, Jensen, Jan   +3 more
openaire   +2 more sources

Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo

Journal of Inflammation Research, 2021
Yuhan Chen,1,* Yuanyuan Chen,1,* Xueze Jiang,1 Mengkun Shi,2 Zhenwei Yang,1 Zhiyong Chen,1 Xuesheng Hua,1 Jie Chen,1 Yuepeng Wang1 1Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, People’
Chen Y, Chen Y, Jiang X, Shi M, Yang Z, Chen Z, Hua X, Chen J, Wang Y   +8 more
doaj  

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis [PDF]

, 2005
Background: Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during embryonic SMG development. To address this question, we have analyzed the SMG phenotype in
Abichaker, George, Witcher, Daniel, Hajihosseini, Mohammad K., Jaskoll, Tina, Bellusci, Saverio, Melnick, Michael, Sala, Frederic G.   +6 more
core   +1 more source

Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung.

PLoS ONE, 2020
CRISPR/Cas9-mediated gene editing often generates founder generation (F0) mice that exhibit somatic mosaicism in the targeted gene(s). It has been known that Fibroblast growth factor 10 (Fgf10)-null mice exhibit limbless and lungless phenotypes, while ...
Munenori Habuta, Akihiro Yasue, Ken-Ichi T Suzuki, Hirofumi Fujita, Keita Sato, Hitomi Kono, Ayuko Takayama, Tetsuya Bando, Satoru Miyaishi, Seiichi Oyadomari, Eiji Tanaka, Hideyo Ohuchi   +11 more
doaj   +1 more source

Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects

Journal of Translational Medicine, 2020
Background Conotruncal defects (CTDs) are a type of heterogeneous congenital heart diseases (CHDs), but little is known about their etiology. Increasing evidence has demonstrated that fibroblast growth factor (FGF) 8 and FGF10 may be involved in the ...
Kun Sun, Shuang Zhou, Qingjie Wang, Zhuo Meng, Jiayu Peng, Yue Zhou, Wenting Song, Jian Wang, Sun Chen   +8 more
doaj   +1 more source

Interrogation of a lacrimo-auriculo-dento-digital syndrome protein reveals novel modes of fibroblast growth factor 10 (FGF10) function [PDF]

, 2016
Heterozygous mutations in the gene encoding fibroblast growth factor 10 (FGF10) or its cognate receptor, FGF-receptor 2 IIIb (FGFR2-IIIb) result in two human syndromes - LADD (lacrimo-auriculo-dento-digital) and ALSG (Aplasia of lacrimal and salivary ...
Mikolajczak, Marta, Goodman, Timothy, Hajihosseini, Mohammad K., Hajihosseini, Mohammad, Timothy, Goodman   +4 more
core   +1 more source

FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias [PDF]

European Journal of Human Genetics, 2007
Hypospadias is a common malformation, which results from failure of urethral tube closure, and whose molecular mechanisms are still largely unknown. The normal genital development is orchestrated by the urethral plate epithelium (UPE), at the genital tubercle (GT), which has polarizing activity, controlling a network of epithelial-mesenchymal ...
Ana, Beleza-Meireles, Fredrik, Lundberg, Kristina, Lagerstedt, Xiaolei, Zhou, Davood, Omrani, Louise, Frisén, Agneta, Nordenskjöld   +6 more
openaire   +2 more sources

FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response

Frontiers in Pharmacology, 2019
The process of axonal regeneration after peripheral nerve injury (PNI) is slow and mostly incomplete. Previous studies have investigated the neuroprotective effects of fibroblast growth factor 10 (FGF10) against spinal cord injury and cerebral ischemia ...
Lvpeng Dong, Lvpeng Dong, Rui Li, Rui Li, Duohui Li, Beini Wang, Yingfeng Lu, Peifeng Li, Fangzheng Yu, Yonglong Jin, Xiao Ni, Yanqing Wu, Shengnan Yang, Guanxi Lv, Xiaokun Li, Jian Xiao, Jian Wang   +16 more
doaj   +1 more source

Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo

Frontiers in Endocrinology, 2020
The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but in vitro differentiation remains difficult.
Qingsong Ran, Qiliang Zhou, Kanako Oda, Akihiro Yasue, Manabu Abe, Xulu Ye, Yingchun Li, Toshikuni Sasaoka, Kenji Sakimura, Yoichi Ajioka, Yasuo Saijo   +10 more
doaj   +1 more source