Results 51 to 60 of about 11,138 (199)

176 The Role of Fgf10 for Alveogenesis in Bronchopulmonary Dysplasia [PDF]

Archives of Disease in Childhood, 2012
Background and aim Bronchopulmonary dysplasia (BPD) is associated with impaired alveolar growth and pathologic vascularization. As a chronic lung disease it remains an important complication for preterm infants, especially born before 28th week of gestational age.
C. Chao, D. A. Alam, C. Tiozzo, R. Virender, S. Bellusci   +4 more
openaire   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Fibroblast Growth Factor 10 Attenuates Renal Damage by Regulating Endoplasmic Reticulum Stress After Ischemia–Reperfusion Injury

Frontiers in Pharmacology, 2020
Renal ischemia–reperfusion (I/R) injury is a predominant cause of acute kidney injury (AKI), the pathologic mechanism of which is highly complex involving reactive oxygen species (ROS) accumulation, inflammatory response, autophagy, apoptosis as well as ...
Xiaohua Tan, Xiaohua Tan, Lixia Yu, Ruo Yang, Qianyu Tao, Lijun Xiang, Jian Xiao, Jin-San Zhang, Jin-San Zhang   +8 more
doaj   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Fgf10 overexpression during homeostasis does not cause metaplasia of the gastric epithelium.

, 2013
(A–C) CDX2, a marker of intestinal metaplasia (IM), immunostaining in adult colon (positive control) (A), control littermate (R26rtTA/+; tet(O)Fgf10/+ without dox) (B) and mutant Fgf10 overexpressing mice (R26rtTA/+; tet(O)Fgf10/+ with dox) (C).
Saverio Bellusci (1874743), Henri R. Ford (300700), Allison L. Speer (300698), Denise Al Alam (59722), Frederic G. Sala (300699), Tracy C. Grikscheit (300701)   +5 more
core   +1 more source

FGF10 ameliorates lipopolysaccharide-induced acute lung injury in mice via the BMP4-autophagy pathway

Frontiers in Pharmacology, 2022
Introduction: Damage to alveolar epithelial cells caused by uncontrolled inflammation is considered to be the main pathophysiological change in acute lung injury.
Xiaoxia Kong, Xiaoxia Kong, Liling Lu, Liling Lu, Daopeng Lin, Daopeng Lin, Lei Chong, Shunhang Wen, Yaokai Shi, Lidan Lin, Liqin Zhou, Hongyu Zhang, Hongyu Zhang, Hailin Zhang   +13 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Shape self-regulation in early lung morphogenesis. [PDF]

PLoS ONE, 2012
The arborescent architecture of mammalian conductive airways results from the repeated branching of lung endoderm into surrounding mesoderm. Subsequent lung's striking geometrical features have long raised the question of developmental mechanisms ...
Raphaël Clément, Pierre Blanc, Benjamin Mauroy, Vincent Sapin, Stéphane Douady   +4 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Role of Fibroblast Growth Factor 10 in Mesenchymal Cell Differentiation During Lung Development and Disease

Frontiers in Genetics, 2018
During organogenesis and pathogenesis, fibroblast growth factor 10 (Fgf10) regulates mesenchymal cell differentiation in the lung. Different cell types reside in the developing lung mesenchyme. Lineage tracing in vivo was used to characterize these cells
Jin Wu, Xuran Chu, Xuran Chu, Chengshui Chen, Saverio Bellusci, Saverio Bellusci, Saverio Bellusci   +6 more
doaj   +1 more source