Results 61 to 70 of about 11,138 (199)

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

A Functional Polymorphism at the FGF10 Gene Is Associated With Extreme Myopia

Investigative Opthalmology & Visual Science, 2013
Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia.The expression levels of FGF10 gene were compared among the ...
Edward, Hsi, Ku-Chung, Chen, Wan-Shu, Chang, Ming-Lung, Yu, Chung-Ling, Liang, Suh-Hang Hank, Juo   +5 more
openaire   +2 more sources

RNA-Seq explores the functional role of the fibroblast growth factor 10 gene in bovine adipocytes differentiation [PDF]

Animal Bioscience
Objective The present study was executed to explore the molecular mechanism of fibroblast growth factor 10 (FGF10) gene in bovine adipogenesis. Methods The bovine FGF10 gene was overexpressed through Ad-FGF10 or inhibited through siFGF10 and their ...
Nurgulsim Kaster, Rajwali Khan, Ijaz Ahmad, Kazhgaliyev Nurlybay Zhigerbayevich, Imbay Seisembay, Akhmetbekov Nurbolat, Shaikenova Kymbat Hamitovna, Omarova Karlygash Mirambekovna, Makhanbetova Aizhan Bekbolatovna, Tlegen Garipovich Amangaliyev, Ateikhan Bolatbek, Titanov Zhanat Yeginbaevich, Shakoor Ahmad, Zan Linsen, Begenova Ainagul Baibolsynovna   +14 more
doaj   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

FGF10 is an essential regulator of tracheal submucosal gland morphogenesis

Developmental Biology, 2019
Mucus secretion and mucociliary clearance are crucial processes required to maintain pulmonary homeostasis. In the trachea and nasal passages, mucus is secreted by submucosal glands (SMGs) that line the airway, with an additional contribution from goblet cells of the surface airway epithelium.
May, Alison Judith, Teshima, Tathyane HN, Noble, Alistair, Tucker, Abigail Saffron   +3 more
openaire   +4 more sources

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

Cell Reports, 2014
Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 ...
Kristina Hertzler-Schaefer, Grinu Mathew, Ally-Khan Somani, Sunil Tholpady, Madhavi P. Kadakia, Yiping Chen, Dan F. Spandau, Xin Zhang   +7 more
doaj   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Fgf10^iCre is a null allele for Fgf10. E12.5 Fgf10^iCre/iCre embryos show agenesis of the limbs (A, A’) and lung (B, B’) as well as cecal and colonic atresia (C, C’).

, 2012
Arrowheads indicate sites of limb agenesis and dashed lines mark the epithelium in the cecum. Fgf10iCre/+ embryos were used as controls. (D) Fgf10 relative mRNA levels as quantified by qPCR.
BreAnne MacKenzie (158285), Kerstin Goth (158290), Saverio Bellusci (1874743), Elie El Agha (158281), Stijn P. De Langhe (38981), Virender K. Rehan (158303), Robert Voswinckel (158296), Gianni Carraro (38982), Mohammad K. Hajihosseini (38987), Denise Al Alam (59722)   +9 more
core   +1 more source

c-Myc regulates proliferation and Fgf10 expression in airway smooth muscle after airway epithelial injury in mouse. [PDF]

PLoS ONE, 2013
During lung development, Fibroblast growth factor 10 (Fgf10), which is expressed in the distal mesenchyme and regulated by Wnt signaling, acts on the distal epithelial progenitors to maintain them and prevent them from differentiating into proximal ...
Thomas Volckaert, Alice Campbell, Stijn De Langhe   +2 more
doaj   +1 more source