Results 71 to 80 of about 11,138 (199)
Validation of a Novel Fgf10Cre–ERT2 Knock-in Mouse Line Targeting FGF10Pos Cells Postnatally
Frontiers in Cell and Developmental Biology, 2021 Fgf10 is a key gene during development, homeostasis and repair after injury. We previously reported a knock-in Fgf10Cre–ERT2 line (with the Cre-ERT2 cassette inserted in frame with the start codon of exon 1), called thereafter Fgf10Ki–v1, to target ...
Xuran Chu +17 more
doaj +1 more source
Advanced Science, EarlyView.Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu +9 more
wiley +1 more source
Fgf10 expression and function in early ureter and kidney development.
, 2013 (A,B) In situ hybridization in transverse sections of E10.5 wild type embryos reveals that Fgf10 and Gdnf are expressed in metanephric mesenchyme (arrows).
Gail R. Martin (367909) +8 more
core +1 more source
Frontiers in Genetics, 2019 Members of the PEA3 transcription factors are emerging as bone fide targets for fibroblast growth factor (FGF) signaling. Among them, ETV4 and ETV5 appear to mediate FGF10 signaling during early embryonic lung development.
Matthew R. Jones +13 more
doaj +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, EarlyView.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source
Identification and analysis of a novel nuclear role of Fibroblast Growth Factor 10 (FGF10) [PDF]
, 2016 Fibroblast growth factor 10 (FGF10) is a paracrine molecule, serving crucial mesenchymal-to-epithelial signalling roles during development and postnatally.
Mikolajczak, Marta
core +2 more sources
The Role of Fibroblast Growth Factor 10 Signaling in Duodenal Atresia
Frontiers in Pharmacology, 2020 IntroductionDuodenal atresia (DA) is a congenital bowel obstruction requiring major surgery in the first week of life. Three morphological phenotypes are described, reflecting increasing degrees of obstruction and discontinuity of the duodenum. The cause
Matthew L. M. Jones +15 more
doaj +1 more source
Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension
Cell Proliferation, EarlyView.Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang +14 more
wiley +1 more source
Tbx4 and Tbx5 interact with Fgf10, but FGF10 fails to rescue Tbx4- and Tbx5-deficient lungs.
, 2012 (A–E) Lungs of different genotypes at E18.5. Tbx4;Tbx5 double heterozygous lungs (B) are smaller than control lungs (A). Tbx4;Tbx5;Fgf10 triple heterozygous lungs (C) are smaller than the double heterozygous lungs (B) but comparable in size to the lung ...
Ripla Arora (145097) +2 more
core +1 more source
FGF Signaling in Lung Development and Disease: Human Versus Mouse
Frontiers in Genetics, 2019 Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents.
Soula Danopoulos +2 more
doaj +1 more source