Results 41 to 50 of about 11,138 (199)

FGF10 Signaling in Heart Development, Homeostasis, Disease and Repair [PDF]

Frontiers in Genetics, 2018
Essential muscular organ that provides the whole body with oxygen and nutrients, the heart is the first organ to function during embryonic development. Cardiovascular diseases, including acquired and congenital heart defects, are the leading cause of mortality in industrialized countries.
Hubert, Fabien, Payan, Sandy, Rochais, Francesca   +2 more
openaire   +3 more sources

Influences of FGF3 and FGF10 on Migration and Invasion of Human Ovarian Cancer SKOV3 Cells and Relation Between These Influences and Wnt/β-catenin Signaling Pathway

Zhongliu Fangzhi Yanjiu, 2018
Objective To explore the influences of FGF3 and FGF10 on migration and invasion of human ovarian cancer SKOV3 cells and relation between these influences and Wnt/β-catenin signaling pathway. Methods Human ovarian cancer SKOV3 cells were cultured in vitro
WANG Jia, ZHU Kexiu
doaj   +1 more source

FGF10 Triggers de novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche Cells

, 2022
Bronchopulmonary dysplasia (BPD) is a neonatal lung disease developing in premature babies characterized by arrested alveologenesis and associated with decreased Fibroblast growth factor 10 (FGF10) expression. One-week hyperoxia (HYX) exposure of newborn
Heiner, M., Taghizadeh, Sara, Guenther, Stefan, Glaser, Lea, Goth, Kerstin, Glaser, L., Weissmann, Norbert, Gersmann, L., Kraut, Simone, Chao, Cho-Ming, Bellusci, S., Minoo, Parviz, Vazquez-Armendariz, A., Weissmann, N., Koepke, J., Samakovlis, Christos, Bellusci, Saverio, Minoo, P., Boyer, Laurent, Ehrhardt, Harald, Chao, C., Heiner, Monika, Boyer, L., Ricci, Francesca, Herold, S., Kraut, S., Taghizadeh, S., Michel, G., Vazquez-Armendariz, Ana Ivonne, Michel, Gabriela, Koepke, Janine, Ehrhardt, H., Rivetti, Stefano, Aquila, Giorgio, Rivetti, S., Goth, K., Ricci, F., Gersmann, Luisa, Guenther, S., Herold, Susanne, Samakovlis, C., Aquila, G., Norbert Weissmann, Harald Ehrhardt, Kerstin Goth, Simone Kraut, Christos Samakovlis, Janine Koepke, Francesca Ricci, Gabriela Michel, Giorgio Aquila, Lea Glaser, Cho-Ming Chao, Stefano Rivetti, Ana Ivonne Vazquez-Armendariz, Laurent Boyer, Luisa Gersmann, Susanne Herold, Saverio Bellusci, Stefan Guenther, Sara Taghizadeh, Parviz Minoo, Monika Heiner   +62 more
core   +1 more source

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10 [PDF]

PLoS Genetics, 2010
GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans. Furthermore, many other mutant genes that cause renal agenesis exert their effects via the GDNF/RET pathway.
Michos, Odyssé, Cebrian, Cristina, Hyink, Deborah, Grieshammer, Uta, Williams, Linda, D'Agati, Vivette, Licht, Jonathan D, Martin, Gail R, Costantini, Frank   +8 more
openaire   +6 more sources

FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling

Frontiers in Genetics, 2018
Ischemia-reperfusion (I/R) is a common cause of acute kidney injury (AKI), which is associated with high mortality and poor outcomes. Autophagy plays important roles in the homeostasis of renal tubular cells (RTCs) and is implicated in the pathogenesis ...
Xiaohua Tan, Xiaohua Tan, Hongmei Zhu, Qianyu Tao, Lisha Guo, Tianfang Jiang, Le Xu, Ruo Yang, Xiayu Wei, Jin Wu, Xiaokun Li, Xiaokun Li, Jin-San Zhang, Jin-San Zhang, Jin-San Zhang   +14 more
doaj   +1 more source

Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development

Frontiers in Genetics, 2018
Members of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these family members, FGF10, is largely expressed in mesenchymal tissues and is essential for postnatal ...
Michaela Prochazkova, Jan Prochazka, Pauline Marangoni, Ophir D. Klein   +3 more
doaj   +1 more source

Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other Organs

Frontiers in Cell and Developmental Biology, 2021
The adult human lung is constantly exposed to irritants like particulate matter, toxic chemical compounds, and biological agents (bacteria and viruses) present in the external environment.
Manuela Marega, Manuela Marega, Chengshui Chen, Saverio Bellusci, Saverio Bellusci   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation

, 2009
We have previously reported that fibroblast growth factor 10 (FGF10) is crucial for the survival and proliferation of progenitor cells during embryonic gastrointestinal development.
Kanard, Robert J, Wang, Jin, Pierre M. Del Moral, Wang, Kasper S, Del Moral, Pierre M, Saverio Bellusci, Tai, Cindy C, Chokshi, Nikunj, Jin Wang, Sala, Frederic G, Al Alam, Denise, Ford, Henri R, Cindy C. Tai, Curtis, Jennifer L, Henri R. Ford, Kasper S. Wang, Grishin, Anatoly, Robert J. Kanard, Bellusci, Saverio, Jennifer L. Curtis, Denise Al Alam, Burns, R Cartland, Frederic G. Sala, R. Cartland Burns, Nikunj Chokshi, Anatoly Grishin   +25 more
core   +1 more source

FGF10: A potential target for heart regeneration

Archives of Cardiovascular Diseases Supplements, 2018
Introduction In mammals, cardiomyocyte proliferation decreases rapidly after birth resulting in limited regenerative capacities in the adult heart. Deciphering developmental mechanisms controlling cardiomyocyte proliferation may thus identify new therapeutic targets to promote adult cardiomyocyte cell cycle re-entry and therefore, cardiac regeneration.
F. Hubert, S. Payan, R. Sturny, R.G. Kelly, F. Rochais   +4 more
openaire   +1 more source