Results 151 to 160 of about 1,606,538 (419)

Successful Long-term Treatment with Modified Dose Pemigatinib in FGFR2-BICC1 Intrahepatic Cholangiocarcinoma: A Case Report

Journal of Cancer Research and Practice
Patients with advanced intrahepatic cholangiocarcinoma (iCCA) have a poor prognosis. Recent advances in molecular profiling offer hope by enabling targeted treatment for those with specific mutations, potentially increasing survival rates.
Kuan-Chang Lai, Ming-Huang Chen
doaj   +1 more source

Analyzing the Dynamic Relationship between Tumor Growth and Angiogenesis in a Two Dimensional Finite Element Model [PDF]

arXiv, 2007
Employing a novel two-dimensional computational model we have simulated the feedback between angiogenesis and tumor growth dynamics. Analyzing vessel formation and elongation towards the concentration gradient of the tumor-derived angiogenetic basic fibroblast growth factor, bFGF, we assumed that prior to the blood vessels reaching the tumor surface ...
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization.

Blood, 1998
Platelet factor 4 (PF-4) inhibits angiogenesis in vitro and in vivo. The mechanism of inhibition is poorly understood. We have investigated the mechanism of inhibition by examining the interaction of PF-4 and the fibroblast growth factor-2 (FGF-2 ...
C. Perollet, Zhongchao Han, C. Savona, J. Caen, A. Bikfalvi   +4 more
semanticscholar   +1 more source

Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud [PDF]

, 2004
Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development.
Bates, Carlton M., Baum, Michel, Grady, Sandy, Kegg, Heather, Robinson, Michael L., Truong, Hoang-Trang, Zhao, Haotian   +6 more
core   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways.

Stem Cells and Development, 2008
Bone marrow mesenchymal stem cells (BMMSCs) have the capacity for self-renewal, and differentiation into a variety of cell types. They thus represent an attractive source of material for cell therapy.
S. Choi, Su-jin Kim, Ji‐Hyun Choi, Chi-Yeon Park, W. Shim, D. Lim   +5 more
semanticscholar   +1 more source

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj  

Model of the early development of thalamo-cortical connections and area patterning via signaling molecules [PDF]

Journal of Computational Neuroscience 17: 347-363 (2004), 2004
The mammalian cortex is divided into architectonic and functionally distinct areas. There is growing experimental evidence that their emergence and development is controlled by both epigenetic and genetic factors. The latter were recently implicated as dominating the early cortical area specification.
arxiv  

Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2 [PDF]

, 2005
Extracellular ATP enhances the mitogenic activity of fibroblast growth factor-2 (FGF2) in astrocytes, but the molecular mechanism underlying this synergistic interaction is not known.
BF King, C Ho, CJ Gallagher, CJ Marshall, CJ Sherr, D Ferrari, D Schiffer, D Wang, F Doetsch, F Eclancher, F Perraud, FP Gendron, FP Gendron, G Burnstock, G Lenz, G Lenz, GL Peterson, H Franke, J Silver, JB Cavanagh, JD Weber, JJ Yang, JL Ridet, Joseph T. Neary, JT Neary, JT Neary, JT Neary, JT Neary, JT Neary, K Roovers, M Fumagalli, MC Jacques-Silva, MP Abbracchio, MP Rathbone, N Huang, N Latov, NE Olson, OR Baricordi, P Zanovello, Q Zhu, QB She, R Seger, RM Tombes, RS Ostrom, SJ Hill-Felberg, SP Finklestein, UK Laemmli, V Budagian, W Panenka, WT Norton, Y Nakatsuji, Y Takamiya, YJ Hou, You-Fang Shi, Yuan Kang   +54 more
core   +2 more sources