Results 121 to 130 of about 961,893 (364)

Fibroblast Growth Factor 23 in Long-Duration Spaceflight [PDF]

Many nutritional factors influence bone, from the basics of calcium and vitamin D, to factors which influence bone through acid/base balance, including protein, sodium, and more.
Bokhari, R., Fields, E., Heer, M., Sibonga, J., Smith, S. M., Zwart, S. R.   +5 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men [PDF]

, 2018
Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate and 1,25 (OH)2 vitamin D3 metabolism and is mainly produced by osteocytes. Its production is upregulated by a variety of factors including 1,25 (OH)2 vitamin D3, high dietary
Bettoni, Carla, Daryadel, Arezoo, Gassmann, Max, Haider, Thomas, Imenez Silva, Pedro H, Pastor-Arroyo, Eva Maria, Schnitzbauer, Udo, Wagner, Carsten A, Wenger, Roland H   +8 more
core   +1 more source

Phosphate-sensing mechanisms and functions of phosphate as a first messenger

Endocrine Journal
Bone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of ...
Yuichi Takashi
doaj   +1 more source

Analyzing the Dynamic Relationship between Tumor Growth and Angiogenesis in a Two Dimensional Finite Element Model [PDF]

arXiv, 2007
Employing a novel two-dimensional computational model we have simulated the feedback between angiogenesis and tumor growth dynamics. Analyzing vessel formation and elongation towards the concentration gradient of the tumor-derived angiogenetic basic fibroblast growth factor, bFGF, we assumed that prior to the blood vessels reaching the tumor surface ...
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

The production of fibroblast growth factor 23 is controlled by TGF-β2

Scientific Reports, 2017
Transforming growth factor-β (TGF-β) is a cytokine produced by many cell types and implicated in cell growth, differentiation, apoptosis, and inflammation.
Martina Feger, Philipp Hase, Bingbing Zhang, Frank Hirche, Philipp Glosse, Florian Lang, Michael Föller   +6 more
doaj   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Fibroblast Growth Factor-23 in Bed Rest and Spaceflight [PDF]

Many nutritional factors influence bone, from the basics of calcium and vitamin D, to factors which influence bone through acid/base balance, including protein, sodium, and more.
Bokhari, R., Fields, E., Heer, M., Sibonga, J., Smith, S. M., Zwart, S. R   +5 more
core   +1 more source

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin [PDF]

, 2005
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a ...
A Bucht, AN Akbar, AN Akbar, Arne N Akbar, B Relic, BP Leung, C Jakubzick, Caroline Gordon, CD Buckley, CD Buckley, Chi-Yeung Lee, Christopher D Buckley, CM Weyand, D Pilling, DV Jovanovic, E Berglin, Emma J Ross, F Fossiez, F Santiago-Schwarz, FC Arnett, FM Brennan, FP Heinzel, Francesco Falciani, G Husby, G Parsonage, GS Firestein, GS Firestein, GS Firestein, H Visser, HR Schumacher, IB McInnes, J Kaufman, Janet M Lord, JM Bathon, K Raza, Karim Raza, L Breiman, LA Joosten, LJ Zhou, M Boers, M Salmon, M Salmon, M Sebbag, MC Blades, MG Chiaramonte, Mike Salmon, MJ Jacobs, MM Nielen, N Matthews, NJ Zvaifler, P Kurki, P Miossec, PG Conaghan, PK Gregersen, PP Tak, R Bucala, R Gerli, RL Modlin, S John Curnow, SJ Curnow, SK Seo, T Mottonen, T Pap, TF Cox, Y Benjamini, Y Morita   +65 more
core   +2 more sources