Results 121 to 130 of about 536,398 (346)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

Fibroblast growth factor 23 and acute kidney injury [PDF]

Pediatric Nephrology, 2014
Fibroblast growth factor 23 (FGF23), which is produced in bone, participates in the maintenance of phosphate metabolism and can serve as a biomarker for adverse cardiovascular outcomes in patients with chronic kidney disease and end-stage renal disease.
Javier A, Neyra, Orson W, Moe, Ming Chang, Hu   +2 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Phosphate-sensing mechanisms and functions of phosphate as a first messenger

Endocrine Journal
Bone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of ...
Yuichi Takashi
doaj   +1 more source

Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats

Journal of Veterinary Internal Medicine, 2019
Background Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is increased in azotemic cats with chronic kidney disease (CKD) and predictive of the onset of azotemia in older cats.
Hannah J. Sargent, Rosanne E. Jepson, Yu‐mei Chang, Vincent C. Biourge, Esther S. Bijsmans, Jonathan Elliott   +5 more
doaj   +1 more source

Fibroblast Growth Factor 23 in Long-Duration Spaceflight [PDF]

Many nutritional factors influence bone, from the basics of calcium and vitamin D, to factors which influence bone through acid/base balance, including protein, sodium, and more.
Bokhari, R., Fields, E., Heer, M., Sibonga, J., Smith, S. M., Zwart, S. R.   +5 more
core   +1 more source

Circulating Sclerostin Levels Are Decreased in Patients with Endogenous Hypercortisolism and Increase after Treatment [PDF]

, 2012
CONTEXT: Increased bone fragility is a frequent complication of hypercortisolism due predominantly to suppression of bone formation. Sclerostin is an osteocyte-produced negative regulator of bone formation, which is up-regulated by glucocorticoids in ...
Eerden, A.W. van der, Hamdy, N.A.T., Heijer, M. den, Hermus, A.R., Lierop, A.H. van, Papapoulos, S.E.   +5 more
core   +1 more source

Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.

Kidney International, 2019
Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis, and its early rise in patients with chronic kidney disease (CKD) is independently associated with all-cause mortality.
Daniela Egli-Spichtig, P. H. Imenez Silva, Bob Glaudemans, N. Gehring, Carla Bettoni, Martin Y. H. Zhang, E. Pastor-Arroyo, Désirée Schönenberger, M. Rajski, D. Hoogewijs, F. Knauf, B. Misselwitz, I. Frey-Wagner, G. Rogler, D. Ackermann, B. Ponte, M. Pruijm, A. Leichtle, G. Fiedler, M. Bochud, V. Ballotta, S. Hofmann, Farzana Perwad, M. Föller, F. Lang, R. Wenger, I. Frew, C. Wagner   +27 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source