A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]
arXiv, 2020 Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients [PDF]
Armaghane Danesh Bimonthly Journal, 2022 Background & aim: Considering that overweight and obesity in transplant patients are considered as a risk factor for the occurrence of metabolic disorders, heart diseases and reduced kidney function, therefore, the purpose of the present study was to ...
V Ebrahimzadeh Attari +5 more
doaj
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Circulating Sclerostin Levels Are Decreased in Patients with Endogenous Hypercortisolism and Increase after Treatment [PDF]
, 2012 CONTEXT: Increased bone fragility is a frequent complication of hypercortisolism due predominantly to suppression of bone formation. Sclerostin is an osteocyte-produced negative regulator of bone formation, which is up-regulated by glucocorticoids in ...
Eerden, A.W. van der +5 more
core +1 more source
Serum Fibroblast Growth Factor 23 Level and Liver Fat Content in MAFLD: A Community-Based Cohort
Diabetes, Metabolic Syndrome and Obesity, 2021 Weijie Cao,* Yiting Xu,* Yun Shen, Yufei Wang, Xiaojing Ma, Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical ...
Cao W, Xu Y, Shen Y, Wang Y, Ma X, Bao Y
doaj
Differential response of idiopathic sporadic tumoral calcinosis to bisphosphonates
Indian Journal of Endocrinology and Metabolism, 2014 Context: Tumoral calcinosis is a disorder of phosphate metabolism characterized by ectopic calcification around major joints. Surgery is the current treatment of choice, but a suboptimal choice in recurrent and multicentric lesions. Aims: To evaluate the
Karthik Balachandran +4 more
doaj +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Significance of Fibroblast Growth Factor 23 in Acute Kidney Injury
Acta Clinica Croatica, 2015 Acute kidney injury is a clinical syndrome associated with increased patient morbidity and mortality, as well as serious short-term and long-term consequences, especially in the perioperative period.
Nikolina Bašić-Jukić +5 more
doaj
The micromechanics of fluid-solid interactions during growth in porous soft biological tissue [PDF]
arXiv, 2007 In this paper we address some modelling issues related to biological growth. Our treatment is based on a recently-proposed, general formulation for growth within the context of Mixture Theory (Journal of the Mechanics and Physics of Solids, 52, 2004, 1595--1625).
arxiv