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Fibroblast growth factor 23 and phosphate homeostasis
Current Opinion in Nephrology and Hypertension, 2019The current review highlights recent advances in the area of renal tubular phosphate transport and its regulation by fibroblast growth factor 23 (FGF23), a potent regulator of phosphate homeostasis.Recent studies demonstrate that FGF23 binds to both membrane and soluble form of α-klotho to activate FGF receptor signaling pathways.
Shanthi, Balani, Farzana, Perwad
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Fibroblast Growth Factor 23–Mediated Bone Disease
Endocrinology and Metabolism Clinics of North America, 2017Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders ...
Anda R, Gonciulea +1 more
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Fibroblast growth factor 23 and the heart
Current Opinion in Nephrology and Hypertension, 2012Elevated serum levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) are strongly associated with chronic kidney disease (CKD) progression and mortality, and are also independently associated with left ventricular hypertrophy, a major contributor to cardiovascular disease (CVD) and death in CKD patients.
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Fibroblast growth factor 23 in untreated nephrotic syndrome
Nephrology, 2018AbstractAimDespite its importance in bone and cardiovascular disease in subjects with kidney disease, there are no data on fibroblast growth factor 23 (FGF23) perturbations in nephrotic syndrome. We evaluated FGF23 and markers of mineral bone metabolism in subjects with untreated NS.MethodsIn this cross‐sectional study, we measured circulating levels ...
Ashok Kumar, Yadav +5 more
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Phosphate wasting and fibroblast growth factor-23
Current Opinion in Endocrinology, Diabetes & Obesity, 2013The purpose of this study is to review the regulation of phosphate and recent progress in fibroblast growth factor-23 (FGF-23), a key phosphate regulatory hormone.Phosphate is required for mineralization of bone, muscle strength and a host of biologic functions. Phosphate is sensed by bone that responds with secretion of FGF-23. The major action of FGF-
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Anti-fibroblast growth factor 23 antibody therapy
Current Opinion in Nephrology and Hypertension, 2014The review is intended to provide an update on the expanding knowledge regarding diseases caused by the excess actions of fibroblast growth factor 23 (FGF23) and also on the new therapeutic measures for these diseases, with an emphasis on the anti-FGF23 antibody.FGF23 decreases serum phosphate and 1,25-dihydroxyvitamin D levels.
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Fibroblast Growth Factor 23 (FGF23) and the kidney
The International Journal of Artificial Organs, 2009Phosphate homeostasis in humans is a complex phenomenon involving the interplay of several different organs and circulating hormones. Among the latter, parathyroid hormone (PTH), and vitamin D3 (Vit D3) were thought to be the main regulators of serum phosphate concentration since they mediated the intestinal, renal and bone responses that follow ...
George, Tsagalis +3 more
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The phosphate regulating hormone fibroblast growth factor‐23
Acta Physiologica, 2010AbstractOver the last decade, the regulation of phosphate (Pi) homeostasis has been under intense investigation. By utilizing modern biochemical and genetic tools, the pathophysiological mechanisms behind several known hereditary and acquired hypo‐ and hyperphosphatemic diseases have been clarified. The results of these efforts have opened new insights
R, Marsell, K B, Jonsson
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Fibroblast Growth Factor-23 and Phosphorus Metabolism
2011The understanding of phosphorus metabolism has expanded considerably over the last decade. Recent studies have identified a novel bone-kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis,
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The couple fibroblast growth factor 23 (FGF23)/Klotho
Annales de biologie clinique, 2015The fibrobalst growth factor 23 (FGF23) is a protein secreted in the plasma by bone cells. FGF23 controls phosphate and calcitriol plasma concentration. Its main physiological targets are the kidney and the parathyroid gland. Its production is stimulated by phosphate intake and plasma calcitriol levels.
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