Results 31 to 40 of about 194,657 (287)

THANATOPHORIC DYSPLASIA: LITERATURE REVIEW AND CLINICAL CASE IN MONOCHORIC DIAMNIOTIC TWINS

Неонатологія, хірургія та перинатальна медицина, 2023
Thanatophoric dysplasia, TD (OMIM: 187600, 87601) belongs to the group of FGFR3 chondrodysplasias and is divided into types I and II. The incidence of TD is approximately 1:20,000-50,000 newborns. TD is usually caused by pathogenic variants in the FGFR3
І. Ластівка, А. Бабінцева, В. Анцупова, Л. Брішевац, О. Юрків, І. Малєєва   +5 more
doaj   +1 more source

Prognostic role of fibroblast growth factor receptor 2 in human solid tumors: A systematic review and meta-analysis

Tumor Biology, 2017
In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2
Gang Liu, Disheng Xiong, Rui Xiao, Zhengjie Huang   +3 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 3 Gene: Regulation by Serum Response Factor [PDF]

Molecular Endocrinology, 2004
We have previously identified a cis-acting sequence in the proximal promoter of the fibroblast growth factor receptor 3 (FGFR3) gene that strongly activates transcription in chondrocytic cells. Here we report that the transcriptional activity of this sequence (FRE3) requires serum response factor and its cognate recognition motif, serum response ...
Donald G. McEwen, Martina I. Reinhold, Michael C. Naski   +2 more
openaire   +3 more sources

Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration [PDF]

British Journal of Cancer, 2010
Deregulation of fibroblast growth factor receptor 3 (FGFR3) is involved in several malignancies. Its role in colorectal cancer has not been assessed before.Expression of FGFR3 in human colorectal tumour specimens was analysed using splice variant-specific real-time reverse transcriptase PCR assays.
Klaus Holzmann, Brigitte Marian, M. Klimpfinger, Hendrik Fischer, Fritz Wrba, Sabine Spiegl-Kreinecker, Gudrun Sonvilla, Bettina Grasl-Kraupp, Michael Grusch, Walter Berger, Sigrid Allerstorfer, Christine Heinzle, Christine Gauglhofer, Josef Karner, Stefan Stättner   +14 more
openaire   +3 more sources

Ligand‐binding specificity of human fibroblast growth factor receptor‐3 IIIc [PDF]

FEBS Letters, 1997
Earlier studies indicated that human fibroblast growth factor receptor (FGFR)‐3 IIIc was activated equally well by both FGF‐1 and FGF‐2. In contrast, murine FGFR‐3 IIIc was preferentially activated by FGF‐1. To address this issue, we determined the ligand‐binding specificity of human FGFR‐3 IIIc in comparison with human FGFR‐1 IIIc.
Michael J. Hayman, Hsien-Yi Lin, J. M. Kaplow, Michael Jaye   +3 more
openaire   +3 more sources

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

Frontiers in Immunology, 2021
In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major
Miho Takahashi, Miho Takahashi, Yoshie Umehara, Hainan Yue, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Ge Peng, Hai Le Thanh Nguyen, Hai Le Thanh Nguyen, Risa Ikutama, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Hideoki Ogawa, Shigaku Ikeda, Shigaku Ikeda, François Niyonsaba, François Niyonsaba   +18 more
doaj   +1 more source

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3) Gene Amplification in Patients with Urothelial Carcinoma of the Urinary Bladder

The Iraqi Journal of Medical Sciences, 2021
Background: The fibroblast growth factor receptors (FGFRs) family includes five tyrosine kinase receptors, which play an important role in many cellular mechanisms including proliferation, migration and survival.
Mohsin Al-Marashi, Ban Qasim
doaj   +1 more source

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia [PDF]

Proceedings of the National Academy of Sciences, 2003
Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes.
William A. Horton, Gregory P. Lunstrum, Tomoko Iwata, Chu-Xia Deng, Jay Y. Cho, Changsheng Guo, Monica Torello   +6 more
openaire   +3 more sources

Fibroblast Growth Factor Receptor 3 Mutations in Bladder Tumors Correlate with Low Frequency of Chromosome Alterations

Neoplasia: An International Journal for Oncology Research, 2008
The aim of this study was to analyze the distribution of FGFR3 mutations in bladder tumors of different grade and stage and determine the relation of mutations to chromosomal alterations detected by comparative genomic hybridization (CGH).
Kerstin Junker, Johanna M.M. van Oers, Ellen C. Zwarthoff, Ines Kania, Joerg Schubert, Arndt Hartmann   +5 more
doaj   +1 more source