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Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]
PLoS ONE, 2012 Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue +6 more
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Role of FGF System in Neuroendocrine Neoplasms: Potential Therapeutic Applications
Frontiers in Endocrinology, 2021 Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells dispersed in different organs. Receptor tyrosine kinases are a subclass of tyrosine kinases with a relevant role in several cellular processes ...
Giovanni Vitale +9 more
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OncoTarget, 2016 Basal-like breast cancer is an aggressive tumor subtype with poor prognosis. The discovery of underlying mechanisms mediating tumor cell survival, and the development of novel agents to target these pathways, is a priority for patients with basal-like ...
Kai Hung Tiong +12 more
semanticscholar +1 more source
Thyroid dysfunction from inhibitor of fibroblast growth factor receptor
Experimental Hematology & Oncology, 2019 Background Thyroid dysfunction has not been previously reported in clinical trials of selective fibroblast growth factor receptor (FGFR) inhibitors including AZD4547.
Jeffrey Ahn +3 more
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F1000ResearchFibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler +2 more
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Archives of Medical Science, 2019 Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao +3 more
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A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma
Journal of Biological Chemistry, 2016 Herein, we have identified cross-talk between the Hippo and fibroblast growth factor receptor (FGFR) oncogenic signaling pathways in cholangiocarcinoma (CCA).
Sumera I. Ilyas +10 more
semanticscholar +1 more source
Fibroblast growth factor receptor fusions in cancer: opportunities and challenges
Journal of Experimental & Clinical Cancer Research, 2021 Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many biological processes and developmental functions. Chromosomal translocation of FGFRs result in the formation of chimeric FGFR fusion proteins, which often cause ...
Lingfeng Chen +6 more
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Frontiers in Pharmacology, 2021 Hepatocellular carcinoma (HCC) is a type of primary liver cancer with poor prognosis, and its incidence and mortality rate are increasing worldwide. It is refractory to conventional chemotherapy and radiotherapy owing to its high tumor heterogeneity ...
Haijun Wang +8 more
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Fibroblast Growth Factor Receptor, a Novel Receptor for Vegetative Insecticidal Protein Vip3Aa
Toxins, 2018 Vegetative insecticidal proteins (Vips), which are secreted by some Bacillus thuringiensis strains during vegetative growth, exhibit high virulence to many pests.
Kun Jiang +5 more
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