Results 41 to 50 of about 607,524 (301)

Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects.

Journal of Medicinal Chemistry, 2018
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19 (FGF19) signaling through fibroblast growth factor receptor 4 (FGFR4) has been identified as an ...
Xiaoyun Lu, Hao Chen, A. Patterson, J. Smaill, Ke Ding   +4 more
semanticscholar   +1 more source

Fibroblast Growth Factor Receptor 2

Definitions, 2020
Fibroblast growth factor receptor 2 (821 aa, ~92 kDa) is encoded by the human FGFR2 gene. This protein plays a role in heparin-dependent fibroblast growth factor signaling.

semanticscholar   +1 more source

Roles of Fibroblast Growth Factor Receptors in Carcinogenesis [PDF]

Molecular Cancer Research, 2010
Abstract The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation.
Ellen Margrethe, Haugsten, Antoni, Wiedlocha, Sjur, Olsnes, Jørgen, Wesche   +3 more
openaire   +2 more sources

Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion [PDF]

Yixue xinzhi zazhi
Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide ...
LI Jing, SUN Caixuan, LI Ao, XUE Yilu, WANG Runlin, TANG Yuyun, CAO Yuanyuan   +6 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis

International Journal on Biological Sciences, 2017
Craniosynostosis results from the premature fusion of cranial sutures, with an incidence of 1 in 2,100-2,500 live births. The majority of cases are non-syndromic and involve single suture fusion, whereas syndromic cases often involve complex multiple ...
S. Azoury, Sashank K Reddy, V. Shukla, C. Deng   +3 more
semanticscholar   +1 more source

Derazantinib Inhibits the Bioactivity of Keloid Fibroblasts via FGFR Signaling

Biomedicines, 2023
Keloids are common benign cutaneous pathological fibrous proliferation diseases, which are difficult to cure and easily recur. Studies have shown that fibroblast growth factor receptor-1 (FGFR1) was enhanced in pathological fibrous proliferation diseases,
Shuqia Xu, Yongkang Zhu, Peng Wang, Shaohai Qi, Bin Shu   +4 more
doaj   +1 more source

Mechanism of Fibroblast Growth Factor in Alzheimer's Disease

Xiehe Yixue Zazhi
Alzheimer's disease(AD), the most common neurodegenerative disease, has shown an increasing incidence among younger people. With the onset of disease, most patients' cognitive function will show a progressive decline, bringing a heavy burden to the ...
WU Jiajing, LI Yan, LIANG Yuxia, HUA Huijuan, ZHAO Bo   +4 more
doaj   +1 more source

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

Cell Metabolism, 2015
Summary Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular hypertrophy (LVH).
A. Grabner, A. Amaral, K. Schramm, S. Singh, A. Sloan, Christopher Yanucil, Jihe Li, L. Shehadeh, J. Hare, V. David, Aline Martin, A. Fornoni, G. D. Marco, Dominik Kentrup, S. Reuter, Anna B. Mayer, H. Pavenstädt, J. Stypmann, C. Kuhn, S. Hille, N. Frey, M. Leifheit-Nestler, Beatrice Richter, D. Haffner, Reimar Abraham, J. Bange, Bianca Sperl, A. Ullrich, M. Brand, M. Wolf, C. Faul   +30 more
semanticscholar   +1 more source

Tumor Necrosis Factor Receptor Mediates Fibroblast Growth Factor-Inducible 14 Signaling

Cellular Physiology and Biochemistry, 2017
Tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) engages its sole receptor, fibroblast growth factor–inducible 14 (Fn14), which participates in various inflammatory and immunologic processes.
Xuening Wang, Shengxiang Xiao, Yumin Xia
doaj   +1 more source

Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer

International Journal on Biological Sciences, 2017
Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types of cancers, including breast cancer, lung cancer, gastric ...
Haipeng Lei, C. Deng
semanticscholar   +1 more source