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Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling [PDF]
Clinical and Translational MedicineBackground Metabolic dysfunction–associated steatotic liver disease (MASLD) and advanced fibrotic stages are significant contributors to cirrhosis and liver‐related mortality, yet no therapies directly target fibrosis in the later stages of the disease ...
Xuanxin Yang +20 more
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Physiological Actions of Fibroblast Growth Factor-23
Frontiers in Endocrinology, 2018 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
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Fibroblast growth factor signaling in metabolic regulation
Frontiers in Endocrinology, 2016 The prevalence of obesity is a growing health problem. Obesity is strongly associated with several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin resistance and type 2 diabetes, which all reduce life expectancy and ...
Vera eNies +10 more
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The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Cells, 2021 Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival ...
M. Farooq +3 more
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Fibroblast Growth Factor in Diabetic Foot Ulcer: Progress and Therapeutic Prospects
Frontiers in Endocrinology, 2021 Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and deep-tissue necrosis.
Ye Liu +4 more
semanticscholar +1 more source
Fibroblast Growth Factor Signalling in the Diseased Nervous System
Molecular Neurobiology, 2021 Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. They influence the intricate relationship between myelinating cells and axons as well as the association of astrocytic and microglial ...
L. Klimaschewski, P. Claus
semanticscholar +1 more source
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage
Neural Regeneration Research, 2023 Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer’s disease mouse models and patients, and that it plays a vital role in the learning and memory.
Ruo-Meng Li +4 more
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Indian Journal of Health Sciences and Biomedical Research KLEU, 2020 Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGFs can be classified as intracellular, paracrine, and endocrine FGFs by their action mechanisms.
Leta Shiferaw Melaku, Negeri Debela
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Animals, 2021 The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo +10 more
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Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications
Pharmaceutics, 2020 Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington +3 more
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