Results 41 to 50 of about 11,074,756 (345)

Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

Cells, 2018
Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis.
Navid Sobhani, Anna Ianza, Alberto D’Angelo, Giandomenico Roviello, Fabiola Giudici, Marina Bortul, Fabrizio Zanconati, Cristina Bottin, Daniele Generali   +8 more
doaj   +1 more source

Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]

, 1995
PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
core   +2 more sources

The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]

Journal of Urologic Oncology
Dysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo, Eui Hyun Jung, Sora Yang, Hye Won Lee   +3 more
doaj   +1 more source

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

Kidney International, 2017
Inflammation plays a central role in the etiology of diabetic nephropathy, a global health issue. We observed a significant reduction in the renal expression of fibroblast growth factor 1, a known mitogen and insulin sensitizer, in patients with diabetic
G. Liang, Lintao Song, Zilu Chen, Yuanyuan Qian, Junjun Xie, Long-Wei Zhao, Qian Lin, Guanghui Zhu, Yi Tan, Xiao-Kun Li, M. Mohammadi, Zhi-Feng Huang   +11 more
semanticscholar   +1 more source

Mechanism of Fibroblast Growth Factor in Alzheimer's Disease

Xiehe Yixue Zazhi
Alzheimer's disease(AD), the most common neurodegenerative disease, has shown an increasing incidence among younger people. With the onset of disease, most patients' cognitive function will show a progressive decline, bringing a heavy burden to the ...
WU Jiajing, LI Yan, LIANG Yuxia, HUA Huijuan, ZHAO Bo   +4 more
doaj   +1 more source

Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling

Tumor Biology, 2017
Ovarian cancer is the most lethal gynecologic malignancy, due to its high propensity for metastasis. Cancer-associated fibroblasts, as the dominant component of tumor microenvironment, are crucial for tumor progression. However, the mechanisms underlying
Yuanzhen Sun, Xiaoli Fan, Qing Zhang, Xiaoyu Shi, Guangwei Xu, Cuimin Zou   +5 more
doaj   +1 more source

Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion [PDF]

Yixue xinzhi zazhi
Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide ...
LI Jing, SUN Caixuan, LI Ao, XUE Yilu, WANG Runlin, TANG Yuyun, CAO Yuanyuan   +6 more
doaj   +1 more source

Fibroblast Growth Factors in Schizophrenia [PDF]

Schizophrenia Bulletin, 2009
A large association study by O'Donovan et al recently suggested that genetic variation in fibroblast growth factor receptor (FGFR) 2 increases the risk for developing schizophrenia. Fibroblast growth factors (FGFs) are part of the family of glial growth factors; they control the growth and patterning of specific brain structures and regulate the ...
Afke F, Terwisscha van Scheltinga, Steven C, Bakker, René S, Kahn   +2 more
openaire   +2 more sources

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels

Journal of Lipid Research, 2013
It has been proposed that bile acid suppression of CYP7A1 gene expression is mediated through a gut-liver signaling pathway fibroblast growth factor (FGF)15/19-fibroblast growth factor receptor 4 which is initiated by activation of farnesoid X receptor ...
Quan Shang, Grace L. Guo, Akira Honda, Monica Saumoy, Gerald Salen, Guorong Xu   +5 more
doaj   +1 more source

Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression

Cytokine & growth factor reviews, 2017
Fibrosis is a pathological condition that is characterized by the replacement of dead or damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies account for nearly half of all deaths worldwide.
D. Dolivo, Sara Larson, T. Dominko
semanticscholar   +1 more source