Results 21 to 30 of about 607,524 (301)

Evocalcet with vitamin D receptor activator treatment for secondary hyperparathyroidism

PLoS ONE, 2022
This ad hoc analysis of a previously conducted phase 3 head-to-head comparison study of evocalcet and cinacalcet in secondary hyperparathyroidism patients undergoing maintenance hemodialysis evaluated the efficacy and safety of combined once-daily oral ...
Takashi Shigematsu, Shinji Asada, Yuichi Endo, Takehisa Kawata, Masafumi Fukagawa, Tadao Akizawa   +5 more
doaj   +2 more sources

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Frontiers in Pharmacology, 2021
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu, Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Chengguang Zhao, Huanhai Xu   +7 more
doaj   +1 more source

Dual Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Inhibition Elicits Antitumor Immunity and Enhances Programmed Cell Death-1 Checkpoint Blockade in Hepatocellular Carcinoma

Liver Cancer, 2020
Background and Aims: Combining anti-angiogenic therapy with immune checkpoint blockade with anti-programmed cell death-1 (PD-1) antibodies is a promising treatment for hepatocellular carcinoma (HCC).
Hai-Jing Deng, Anna Kan, Ning Lyu, Luwen Mu, Yi Han, Longzhong Liu, Yanyu Zhang, Youfa Duan, Shuangye Liao, Shaolong Li, Qiankun Xie, Tianxiao Gao, Yanrong Li, Zhenfeng Zhang, Ming Zhao   +14 more
semanticscholar   +1 more source

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct

Animals, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P. Roberto da Costa, Dariusz J. Skarzynski, Graça Ferreira-Dias   +10 more
doaj   +1 more source

Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

Cells, 2021
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological ...
Patrycja Szybowska, Michal Kostas, Jørgen Wesche, Ellen Margrethe Haugsten, Antoni Wiedlocha   +4 more
doaj   +1 more source

Fibroblast Growth Factor Receptor (FGFR) Inhibitors in Urothelial Cancer

The Oncologist, 2020
Dysregulated fibroblast growth factor receptor (FGFR) signaling is associated with several cancers, including urothelial carcinoma. Preclinical studies with FGFR inhibitors have shown significant antitumor activity, which has led to clinical evaluation ...
R. Garje, Josiah An, M. Obeidat, Kranthi Kumar, Hesham Yasin, Y. Zakharia   +5 more
semanticscholar   +1 more source

Reversible Retinopathy Associated with Fibroblast Growth Factor Receptor Inhibitor

Case Reports in Ophthalmology, 2022
We present a case of reversible, pseudovitelliform lesions while a patient was taking pembrolizumab (PDL-1 inhibitor) and erdafitinib (pan-fibroblast growth factor receptor inhibitor) outside of clinical trial protocols. A 61-year-old patient with 3 days
Saagar N. Patel, Mona L. Camacci, Esther M. Bowie   +2 more
doaj   +1 more source

Functions of fibroblast growth factors and their receptors [PDF]

Current Biology, 1995
Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A, Morriss-Kay, G, Jones, E, Heath, J   +3 more
openaire   +2 more sources

Efficacy of BGJ398, a fibroblast growth factor receptor 1–3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations

Cancer Discovery, 2018
BGJ398, a potent and selective pan-fibroblast growth factor receptor (FGFR) antagonist, was prospectively evaluated in patients with metastatic urothelial carcinoma bearing a diverse array of FGFR3 alterations.
S. Pal, J. Rosenberg, J. Hoffman-Censits, R. Berger, D. Quinn, M. Galsky, J. Wolf, C. Dittrich, B. Keam, J. Delord, J. Schellens, G. Gravis, J. Médioni, P. Maroto, V. Sriuranpong, C. Charoentum, H. Burris, V. Grünwald, D. Petrylak, U. Vaishampayan, E. Gez, U. de Giorgi, Jae-Lyun Lee, J. Voortman, Sumati V. Gupta, Sunil Sharma, A. Mortazavi, D. Vaughn, R. Isaacs, K. Parker, Xueying Chen, Kun Yu, D. Porter, Diana Graus Porta, D. Bajorin   +34 more
semanticscholar   +1 more source

Prognostic role of fibroblast growth factor receptor 2 in human solid tumors: A systematic review and meta-analysis

Tumor Biology, 2017
In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2
Gang Liu, Disheng Xiong, Rui Xiao, Zhengjie Huang   +3 more
doaj   +1 more source